Does Early Graft Patency Benefit from Perioperative Statin Therapy? A Propensity Score-Matched Study of Patients Undergoing Off-Pump Coronary Artery Bypass Surgery

Table 1

Baseline and graft characteristics of overall patient before IPW Adjustment.

Patient baseline and; graft characteristics	CS group	DS group	P-Value
	(n=398)	(n=184)
Age, years	62.1	60.2	0.038
≤60yr, %	40.5	49.5	0.042
>60yr, %	59.5	50.5	0.042
Female, %	22.9	18.5	0.230
BMI, kg/m^2	25.3	26.0	0.007
Current smoking, %	50.8	53.3	0.570
Diabetes mellitus, %	37.9	34.8	0.460
Hypertension, %	72.4	60.9	0.005
Dyslipidemia, %	68.8	58.5	0.014
Acute coronary syndrome, %	72.1	66.3	0.160
Left main disease, %	38.4	39.1	0.870
Triple vessel disease, %	86.7	85.3	0.660
Previous PCI, %	16.8	8.2	0.002
Previous MI, %	36.7	29.9	0.110
Stroke or TIA, %	11.6	9.2	0.400
LVEF, %	60.3	59.8	0.540
LDL-C, mg/dL	96.67	93.97	0.410
TC, mmol/L	4.35	4.19	0.090
Creatinine, mg/dL	0.94	0.94	0.850
GFR, mL/min/1.73m^2 †	82.27	84.58	0.120
ALT, U/L	29.17	36.51	0.004
AST, U/L	22.08	23.63	0.170
Medication
Aspirin, %	64.1	78.8	<0.001
Beta-blocker, %	88.7	87.0	0.550
ACEI or ARB, %	48.0	21.2	<0.001
Distal anastomoses (mean distal)	1275 (3.2)	595 (3.2)	0.683
Total graft	1215	561	0.952
SVG	831	378	0.614
Arterial graft	384	183	0.130
Sequential bypass anastomoses	60	34	0.312

IPW = inverse probability weighting; CS = perioperative continuation of statin therapy; DS = discontinuous statin therapy; IHD = ischemic heart disease; PCI = percutaneous coronary intervention; MI = myocardial infarction; TIA = transient ischemic attack; LVEF = left ventricular ejection fraction; LDL-C = low-density lipoprotein cholesterol; TC = total cholesterol; GFR = glomerular filtration rate; ALT = alanine transaminase; AST = aspartate aminotransferase; ACEI = angiotensin-converting-enzyme inhibitor; ARB = angiotensin receptor blocker; SVG = saphenous vein graft.
†The glomerular filtration rate (GFR) was estimated with the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation.