Meta-Analysis of Atrial Fibrillation Ablation in Patients with Systolic Heart Failure

Table 1

Characteristics of patients included in the studies.

Khan

MacDonald

Jones

Hunter

Di Biase

Prabhu

Marrouche

Ablation arm

AV ablation/ CRT

Ablation arm

Rate control

Ablation arm

Rate control

Ablation arm

Rate control

Ablation arm

Amiod-arone

Ablation arm

rate control

Ablation arm

Medical therapy

Mean age (yrs)

60 ± 8

61 ± 8

62.3 ± 6.7

64.4 ± 8.3

64 ± 10

62 ± 9

55 ± 12

60 ± 10

62 ± 10

60 ± 11

59 ± 11

62 ± 9.4

64

64

Female gender

5%

12%

23%

21%

19%

8%

4%

4%

25%

27%

6%

12%

13%

16%

No. of patients

41

40

22

19

26

26

26

24

102

101

33

33

179

184

Follow up (months)

6

6

9.7

6.9

12

12

12

6

24

24

6

6

37.6 ± 20.4

37.4 ± 17.7

Persistent AF

51%

46%

100%

100%

100%

100%

96%

88%

100%

100%

100%

100%

70%

65%

NYHA class

II & III

II & III

II & III

II & III

II & III

II & III

II & III

II & III

II & III

II & III

≥II

≥II

I-IV

I-IV

ICMP

N/A

N/A

50%

47%

38%

27%

23%

29%

62%

65%

0%

0%

40%

52%

NICMP

N/A

N/A

50%

53%

62%

73%

77%

71%

38%

35%

100%

100%

60%

48%

LVEF

27 ± 8

29 ± 7

36.1 ± 11.9

42.9 ± 9.6

22 ± 8

25 ± 7

31.8 ± 7.7

33.7 ± 12.1

29 ± 5

30 ± 8

32 ± 9.4

34 ± 7.8

32.5

31.5

LA diameter (mm)

49 ± 5

47 ± 6

N/A

N/A

50 ± 6

47 ± 7

52 ± 11

50 ± 10

47 ± 4

48 ± 5

48 ± 6

47 ± 8

48

49.5

6 min walk distance

269 ± 54

281 ± 44

317.5 ± 125.8

351.8 ± 117.1

416 ± 78

411 ± 109

N/A

N/A

348 ± 111

350 ± 130

491 ± 147

489 ± 132

N/A

N/A

Peak VO2

N/A

N/A

N/A

N/A

16.3 ± 5.3

18.2 ± 4.8

N/A

NA

N/A

N/A

N/A

N/A

N/A

N/A

Quality of life

89 ± 12

89 ± 11

55.8 ± 19.8

59.2 ± 22.4

42 ± 23

49 ± 21

N/A

N/A

52 ± 24

50 ± 27

N/A

N/A

N/A

N/A