Identification of Differentially Expressed Genes and Signaling Pathways in Acute Myocardial Infarction Based on Integrated Bioinformatics Analysis

Table 4

Top 20 KEGG pathway enrichment analyses of DEGs associated with AMI.

pathway	ID	Gene count	p-value	adjust p-value	Genes
IL-17 signaling pathway	mmu04657	9	2.32E-10	3.30E-08	Cxcl2,S100a8,S100a9,Il6,Cxcl1,Cxcl5,Il1b,Ptgs2,Ccl2
Legionellosis	mmu05134	7	6.85E-09	4.87E-07	Cxcl2,Il6,Cxcl1,Hspa1b,Hspa1a,Il1b,Cd14
Cytokine-cytokine receptor interaction	mmu04060	10	6.80E-07	3.22E-05	Cxcl2,Il1r2,Il6,Cxcl1,Cxcl5,Il1b,Ccl3,Gdf15,Ccl2,Ccr1
Salmonella infection	mmu05132	6	1.38E-06	4.88E-05	Cxcl2,Il6,Cxcl1,Il1b,Ccl3,Cd14
TNF signaling pathway	mmu04668	6	1.03E-05	0.000292216	Cxcl2,Il6,Cxcl1,Il1b,Ptgs2,Ccl2
Rheumatoid arthritis	mmu05323	5	3.97E-05	0.00093865	Il6,Cxcl5,Il1b,Ccl3,Ccl2
Hematopoietic cell lineage	mmu04640	5	7.17E-05	0.001297709	Il1r2,Il6,Il1b,Cd24a,Cd14
Malaria	mmu05144	4	7.31E-05	0.001297709	Il6,Selp,Il1b,Ccl2
Toll-like receptor signaling pathway	mmu04620	5	8.73E-05	0.001377696	Il6,Spp1,Il1b,Ccl3,Cd14
Chagas disease (American trypanosomiasis)	mmu05142	5	0.000105431	0.001497126	Serpine1,Il6,Il1b,Ccl3,Ccl2
Amoebiasis	mmu05146	5	0.000120813	0.001559588	Arg1,Il1r2,Il6,Il1b,Cd14
Human cytomegalovirus infection	mmu05163	7	0.000153378	0.00181497	Il6,Il1b,Ptgs2,Ccl3,Myc,Ccl2,Ccr1
Transcriptional misregulation in cancer	mmu05202	6	0.000179856	0.001964578	Il1r2,Il6,Gadd45g,Myc,Cd14,Igfbp3
Chemokine signaling pathway	mmu04062	6	0.000291266	0.002954267	Cxcl2,Cxcl1,Cxcl5,Ccl3,Ccl2,Ccr1
MAPK signaling pathway	mmu04010	7	0.000358914	0.003397722	Hspa1b,Hspa1a,Il1b,Gadd45g,Myc,Pgf,Cd14
Pertussis	mmu05133	4	0.000404457	0.003589552	Il6,Cxcl5,Il1b,Cd14
Kaposi sarcoma-associated herpesvirus infection	mmu05167	6	0.000451092	0.003767942	Cxcl2,Il6,Cxcl1,Ptgs2,Myc,Ccr1
Prion diseases	mmu05020	3	0.00050479	0.003982228	Il6,Hspa1a,Il1b
AGE-RAGE signaling pathway in diabetic complications	mmu04933	4	0.001183968	0.008848603	Serpine1,Il6,Il1b,Ccl2
HIF-1 signaling pathway	mmu04066	4	0.001367781	0.009711245	Serpine1,Il6,Hmox1,Slc2a1