Research Article

Long-Term Prognosis of Suspected Myocarditis and Cardiomyopathy Associated with Viral Infection of the Myocardial Tissue: A Meta-Analysis of Cohort Studies

Table 1

Detailed characteristics of studies included in the meta-analysis.

StudyCountryStudy periodFollow period (months)PatientsMean ageDiagnosisVirusMethodStudy outcome

Why, H. J. F. et al. 1994United Kingdom1985–198911–50Virus+: 4044.9MC/DCMEVMolecular hybridizationVirus-positive has bad prognosis
Virus−: 76
Figulla, H. R. et al. 1995Germany1987–199225.8 ± 13.7Virus+: 2048.2IDCMEVIn situ hybridizationVirus-positive has better prognosis
Virus−: 57
Fujioka, et al. 2000Japan1997–19986–12Virus+: 949 ± 18IDCMEVPCRVirus-positive has bad prognosis
Virus−: 17
Caforio, A. L. P. et al. 2007Italy1992–200510–54Virus+: 3136 ± 18AMC/BMCHCV/EV/PVB19/ADV/EBV/HSV/CMV/MUMPSPCRVirus-positive has bad prognosis
Virus−: 89
Kindermann, I. et al. 2008Germany1994–200759 ± 42Virus+ : 7942 ± 15Suspected viral myocarditisEV/PVB19/ADV/EBV/HHV6PCRSurvival NO difference
Virus−: 101
Nowalany-Kozielska, E. et al. 2016Poland2004–200710.8–61.2Virus+: 3244.9 ± 10.7DCMHCV/CVB/PVB19/CMVPCRSurvival NO difference
Virus−: 10
Tebbe, U. et al. 2016Germany2003–2013120Virus+: 1754CMHCV/EV/HHV6/PVB19/ADV/EBV/INFAB/HSV/VZVPCRSurvival NO difference
Virus−: 40
Karatolios, K. et al. 2017Germany2004–200858.2 ± 19.8Virus+: 1651.1 ± 11.6DCMPVB19/CMV/HSVPCRSurvival NO difference
Virus−: 39
Kuethe, F. et al. 2017Germany1997–2008120Virus+: 16747.7 ± 12.6CHF/MC/DCMPVB19/EV/ADV/PCR/RT-PCRSurvival NO difference
Virus−: 126
Hjalmarsson, C. et al. 2019Sweden112 ± 57Virus+: 2947 ± 12IDCMPVB19PCRSurvival NO difference
Virus−: 11

MC: myocarditis, CHF: congestive heart failure, CM: cardiomyopathy, DCM/iDCM: dilated/idiopathic dilated cardiomyopathy, VZV: varicella-zoster virus, MUMPS: mumps virus, HSV: herpes simplex virus, EBV: epstein–Barr virus, HHV6: human herpes virus 6, ADV: adenovirus, INFA/B: InfluenzaA/B, CMV: cytomegalovirus, HCV: hepatitis C virus, PVB19: parvovirus-B19, PCR: polymerase chain reaction, RT-PCR: reverse transcription-polymerase chain reaction.