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Cardiovascular Therapeutics
Volume 2019, Article ID 9769724, 10 pages
https://doi.org/10.1155/2019/9769724
Research Article

Outcomes of Cardiac Contractility Modulation: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

1Department of Internal Medicine, Beaumont Health System, Royal Oak, MI, USA
2Department of Cardiovascular Medicine, University of Arkansas for Medical Sciences, USA
3Department of Cardiovascular Medicine, University of Kentucky, Lexington, KY, USA
4Department of Cardiovascular Medicine, Henry Ford Hospital, Detroit, MI, USA

Correspondence should be addressed to Waddah Maskoun; gro.shfh@1uoksamw

Received 25 February 2019; Accepted 19 May 2019; Published 17 June 2019

Academic Editor: Hangang Yu

Copyright © 2019 Ramy Mando et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. R. Bristow, L. A. Saxon, J. Boehmer et al., “Cardiac-resynchronization therapy with or without an implantable defibrillator in advanced chronic heart failure,” The New England Journal of Medicine, vol. 350, no. 21, pp. 2140–2150, 2004. View at Google Scholar
  2. W. T. Abraham, W. G. Fisher, A. L. Smith et al., “Cardiac resynchronization in chronic heart failure,” The New England Journal of Medicine, vol. 346, no. 24, pp. 1845–1853, 2002. View at Google Scholar
  3. A. E. Epstein, J. P. Dimarco, K. A. Ellenbogen et al., “2012 ACCF/AHA/HRS focused update incorporated into the ACCF/AHA/HRS 2008 guidelines for device-based therapy of cardiac rhythm abnormalities: a report of the American college of cardiology foundation/American heart association task force on practice guidelines and the heart rhythm society,” Journal of the American College of Cardiology, vol. 61, no. 3, pp. e6–e75, 2013. View at Publisher · View at Google Scholar · View at Scopus
  4. H. J. Shenkman, V. Pampati, A. K. Khandelwal et al., “Congestive heart failure and QRS duration: establishing prognosis study,” Chest, vol. 122, no. 2, pp. 528–534, 2002. View at Publisher · View at Google Scholar · View at Scopus
  5. J. M. Aranda, G. W. Woo, R. S. Schofield et al., “Management of heart failure after cardiac resynchronization therapy: integrating advanced heart failure treatment with optimal device function,” Journal of the American College of Cardiology, vol. 46, no. 12, pp. 2193–2198, 2005. View at Google Scholar
  6. J. F. Beshai, R. A. Grimm, S. F. Nagueh et al., “Cardiac-resynchronization therapy in heart failure with narrow QRS complexes,” The New England Journal of Medicine, vol. 357, no. 24, pp. 2461–2471, 2007. View at Publisher · View at Google Scholar · View at Scopus
  7. C. B. Brunckhorst, I. Shemer, Y. Mika, S. A. Ben-Haim, and D. Burkhoff, “Cardiac contractility modulation by non-excitatory currents: Studies in isolated cardiac muscle,” European Journal of Heart Failure, vol. 8, no. 1, pp. 7–15, 2006. View at Publisher · View at Google Scholar · View at Scopus
  8. R. Kahwash, D. Burkhoff, and W. T. Abraham, “Cardiac contractility modulation in patients with advanced heart failure,” Expert Review of Cardiovascular Therapy, vol. 11, no. 5, pp. 635–645, 2013. View at Publisher · View at Google Scholar · View at Scopus
  9. F. Abi-Samra and D. Gutterman, “Cardiac contractility modulation: a novel approach for the treatment of heart failure,” Heart Failure Reviews, vol. 21, no. 6, pp. 645–660, 2016. View at Publisher · View at Google Scholar · View at Scopus
  10. S. Röger, R. Schneider, B. Rudic et al., “Cardiac contractility modulation: First experience in heart failure patients with reduced ejection fraction and permanent atrial fibrillation,” Europace, vol. 16, no. 8, pp. 1205–1209, 2014. View at Publisher · View at Google Scholar · View at Scopus
  11. H. Nägele, S. Behrens, and C. Eisermann, “Cardiac contractility modulation in non-responders to cardiac resynchronization therapy,” Europace, vol. 10, no. 12, pp. 1375–1380, 2008. View at Publisher · View at Google Scholar · View at Scopus
  12. S. B. Neelagaru, J. E. Sanchez, S. K. Lau et al., “Nonexcitatory, cardiac contractility modulation electrical impulses: Feasibility study for advanced heart failure in patients with normal QRS duration,” Heart Rhythm, vol. 3, no. 10, pp. 1140–1147, 2006. View at Publisher · View at Google Scholar · View at Scopus
  13. M. Borggrefe, T. Lawo, C. Butter et al., “Randomized, double blind study of non-excitatory, cardiac contractility modulation electrical impulses for symptomatic heart failure,” European Journal of Heart Failure Supplements, vol. 29, no. 8, pp. 1019–1028, 2008. View at Google Scholar
  14. D. Moher, L. Shamseer, M. Clarke et al., “Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement,” Systematic Reviews, vol. 4, no. 1, article 1, 2015. View at Publisher · View at Google Scholar
  15. D. P. Francis, W. Shamim, L. C. Davies et al., “Cardiopulmonary exercise testing for prognosis in chronic heart failure: continuous and independent prognostic value from VE/VCO2 slope and peak VO2,” European Heart Journal, vol. 21, no. 2, pp. 154–161, 2000. View at Publisher · View at Google Scholar · View at Scopus
  16. D. M. Mancini, H. Eisen, W. Kussmaul, R. Mull, L. H. Edmonds Jr., and J. R. Wilson, “Value of peak exercise oxygen consumption for optimal timing of cardiac transplantation in ambulatory patients with heart failure,” Circulation, vol. 83, no. 3, pp. 778–786, 1991. View at Publisher · View at Google Scholar · View at Scopus
  17. P. A. McElroy, J. S. Janicki, and K. T. Weber, “Cardiopulmonary exercise testing in congestive heart failure,” American Journal of Cardiology, vol. 62, no. 2, pp. 35a–40a, 1988. View at Publisher · View at Google Scholar · View at Scopus
  18. C. Demers, R. S. McKelvie, A. Negassa, and S. Yusuf, “Reliability, validity, and responsiveness of the six-minute walk test in patients with heart failure,” American Heart Journal, vol. 142, no. 4, pp. 698–703, 2001. View at Publisher · View at Google Scholar · View at Scopus
  19. T. S. Rector, S. H. Kubo, and J. N. Cohn, “Validity of the minnesota living with heart failure questionnaire as a measure of therapeutic response to enalapril or placebo,” American Journal of Cardiology, vol. 71, no. 12, pp. 1106-1107, 1993. View at Publisher · View at Google Scholar · View at Scopus
  20. A. Kadish, K. Nademanee, K. Volosin et al., “A randomized controlled trial evaluating the safety and efficacy of cardiac contractility modulation in advanced heart failure,” American Heart Journal, vol. 161, no. 2, pp. 329–337.e2, 2011. View at Publisher · View at Google Scholar
  21. W. T. Abraham, K. Kuck, R. L. Goldsmith et al., “A randomized controlled trial to evaluate the safety and efficacy of cardiac contractility modulation,” JACC: Heart Failure, vol. 6, no. 10, pp. 874–883, 2018. View at Publisher · View at Google Scholar
  22. J. P. T. Higgins and S. E. Green, Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0, 2011, http://www.cochrane-handbook.org.
  23. T. Lawo, M. Borggrefe, C. Butter et al., “Electrical signals applied during the absolute refractory period: an investigational treatment for advanced heart failure in patients with normal QRS duration,” Journal of the American College of Cardiology, vol. 46, no. 12, pp. 2229–2236, 2005. View at Google Scholar
  24. D. Burkhoff, I. Shemer, B. Felzen et al., “Electric currents applied during the refractory period can modulate cardiac contractility in vitro and in vivo,” Heart Failure Reviews, vol. 6, no. 1, pp. 27–34, 2001. View at Publisher · View at Google Scholar
  25. C.-M. Yu, J. Y.-S. Chan, Q. Zhang et al., “Impact of cardiac contractility modulation on left ventricular global and regional function and remodeling,” JACC: Cardiovascular Imaging, vol. 2, no. 12, pp. 1341–1349, 2009. View at Publisher · View at Google Scholar · View at Scopus
  26. E. H. Wood, R. L. Heppner, and S. Weidmann, “Inotropic effects of electric currents. I. Positive and negative effects of constant electric currents or current pulses applied during cardiac action potentials. II. Hypotheses: calcium movements, excitation-contraction coupling and inotropic effects.,” Circulation Research, vol. 24, no. 3, pp. 409–445, 1969. View at Publisher · View at Google Scholar · View at Scopus
  27. R. L. Kaufmann, H. Antoni, R. Hennekes, R. Jacob, M. Kohlhardt, and M. J. Lab, “Mechanical response of the mammalian myocardium to modifications of the action potential,” Cardiovascular Research, vol. 5, supplement 1, no. 1, pp. 64–70, 1971. View at Publisher · View at Google Scholar · View at Scopus
  28. J. B. Young, W. T. Abraham, A. L. Smith et al., “Combined cardiac resynchronization and implantable cardioversion defibrillation in advanced chronic heart failure: the MIRACLE ICD Trial,” Journal of the American Medical Association, vol. 289, no. 20, pp. 2685–2694, 2003. View at Publisher · View at Google Scholar
  29. G. L. Botto and G. Russo, “Effect of cardiac resynchronization therapy on quality of life: The best gets the least,” Europace, vol. 14, no. 11, pp. 1537–1539, 2012. View at Publisher · View at Google Scholar · View at Scopus
  30. F. Giallauria, C. Vigorito, M. F. Piepoli, and A. J. Stewart Coats, “Effects of cardiac contractility modulation by non-excitatory electrical stimulation on exercise capacity and quality of life: An individual patient's data meta-analysis of randomized controlled trials,” International Journal of Cardiology, vol. 175, no. 2, pp. 352–357, 2014. View at Publisher · View at Google Scholar · View at Scopus
  31. J. S. W. Kwong, J. E. Sanderson, and C.-M. Yu, “Cardiac contractility modulation for heart failure: A meta-analysis of randomized controlled trials,” Pacing and Clinical Electrophysiology, vol. 35, no. 9, pp. 1111–1118, 2012. View at Publisher · View at Google Scholar · View at Scopus
  32. T. Schau, M. Seifert, J. Meyhfer, M. Neuss, and C. Butter, “Long-term outcome of cardiac contractility modulation in patients with severe congestive heart failure,” Europace, vol. 13, no. 10, pp. 1436–1444, 2011. View at Publisher · View at Google Scholar · View at Scopus
  33. J. Kuschyk, S. Roeger, R. Schneider et al., “Efficacy and survival in patients with cardiac contractility modulation: Long-term single center experience in 81 patients,” International Journal of Cardiology, vol. 183, Article ID 19592, pp. 76–81, 2015. View at Publisher · View at Google Scholar · View at Scopus
  34. M. Liu, F. Fang, X. X. Luo et al., “Improvement of long-term survival by cardiac contractility modulation in heart failure patients: a case-control study,” International Journal of Cardiology, vol. 206, pp. 122–126, 2016. View at Publisher · View at Google Scholar · View at Scopus
  35. S. D. Anker, M. Borggrefe, H. Neuser et al., “Cardiac contractility modulation improves long-term survival and hospitalizations in heart failure with reduced ejection fraction,” European Journal of Heart Failure, 2019. View at Publisher · View at Google Scholar
  36. A. Kloppe, T. Lawo, D. Mijic, F. Schiedat, A. Muegge, and B. Lemke, “Long-term survival with cardiac contractility modulation in patients with NYHA II or III symptoms and normal QRS duration,” International Journal of Cardiology, vol. 209, pp. 291–295, 2016. View at Publisher · View at Google Scholar · View at Scopus