Research Article

Six-Gene Signature Associated with Immune Cells in the Progression of Atherosclerosis Discovered by Comprehensive Bioinformatics Analyses

Table 2

The significant Gene Ontology enrichments of differentially expressed genes (DEGs).

CategoryTermCount value

Upregulated genes
GOTERM_BP_FATGO:0006952~defense response341.78-22
GOTERM_BP_FATGO:0006955~immune response329.60-20
GOTERM_BP_FATGO:0050776~regulation of immune response234.74-15
GOTERM_BP_FATGO:0045087~innate immune response211.47-13
GOTERM_BP_FATGO:0002684~positive regulation of immune system process221.68-13
GOTERM_BP_FATGO:0002682~regulation of immune system process252.27-13
GOTERM_BP_FATGO:0050778~positive regulation of immune response188.88-12
GOTERM_BP_FATGO:0048584~positive regulation of response to stimulus261.26-10
GOTERM_BP_FATGO:0009605~response to external stimulus261.99-10
GOTERM_BP_FATGO:0002250~adaptive immune response142.78-10
GOTERM_BP_FATGO:0006954~inflammatory response164.15-10
GOTERM_BP_FATGO:0002253~activation of immune response156.56-10
GOTERM_BP_FATGO:0002764~immune response-regulating signaling pathway144.79-09
GOTERM_BP_FATGO:0007166~cell surface receptor signaling pathway277.57-09
GOTERM_BP_FATGO:0050900~leukocyte migration121.43-08
GOTERM_BP_FATGO:0002757~immune response-activating signal transduction132.47-08
GOTERM_BP_FATGO:0032101~regulation of response to external stimulus141.75-07
GOTERM_BP_FATGO:0002252~immune effector process142.44-07
GOTERM_CC_FATGO:0044421~extracellular region part334.63-07
GOTERM_CC_FATGO:0005615~extracellular space204.84-07
Downregulated genes
GOTERM_BP_FATGO:0006936~muscle contraction50.00187531
GOTERM_BP_FATGO:0003012~muscle system process50.003885779
GOTERM_BP_FATGO:0006928~movement of cell or subcellular component90.006091447
GOTERM_BP_FATGO:0015672~monovalent inorganic cation transport50.007385488
GOTERM_BP_FATGO:0002028~regulation of sodium ion transport30.007948344
GOTERM_BP_FATGO:0040011~locomotion80.0093652
GOTERM_BP_FATGO:0043269~regulation of ion transport50.011584817
GOTERM_BP_FATGO:0010959~regulation of metal ion transport40.014867703
GOTERM_MF_FATGO:0003779~actin binding40.017959842
GOTERM_BP_FATGO:0006812~cation transport60.018744883
GOTERM_BP_FATGO:0030007~cellular potassium ion homeostasis20.019293154
GOTERM_BP_FATGO:0042391~regulation of membrane potential40.019968055
GOTERM_BP_FATGO:0034765~regulation of ion transmembrane transport40.024929627
GOTERM_BP_FATGO:0034762~regulation of transmembrane transport40.02729303
GOTERM_BP_FATGO:0055075~potassium ion homeostasis20.028804816
GOTERM_MF_FATGO:0008092~cytoskeletal protein binding50.029503547
GOTERM_BP_FATGO:0071805~potassium ion transmembrane transport30.034876856
GOTERM_BP_FATGO:0071804~cellular potassium ion transport30.034876856
GOTERM_BP_FATGO:0032412~regulation of ion transmembrane transporter activity30.03593287
GOTERM_BP_FATGO:0048738~cardiac muscle tissue development30.036287643