Bazedoxifene Plays a Protective Role against Inflammatory Injury of Endothelial Cells by Targeting CD40

Figure 2

The effect of bazedoxifene on migration and ROS production of VECs induced by 25 ng/mL TNF-α. (a) The quantitative result of wound healing. (b) The role of bazedoxifene on the generation of ROS in VECs. VECs were cultured with bazedoxifene with or without TNF-α for 24 h. Subsequently, ROS was stained with dihydroethidium at 5 μg/mL for 30 min. And fluorescence intensity was captured and analyzed by Operetta High Content Imaging System. Scale bar: 100 μm. (c) The expression of CD40. The data were expressed as the (); , compared with the control group; ^# and ^##, compared with the TNF-α group.

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