Bazedoxifene Plays a Protective Role against Inflammatory Injury of Endothelial Cells by Targeting CD40

Figure 3

Bazedoxifene protects VECs against TNF-α-induced inflammation by multiple pathways. VECs were pretreated with bazedoxifene for 30 min, and TNF-α was added in medium for another 24 h treatment. (a, b) The protein levels of p-STAT3 and p-ERK were measured by using western blotting. (c) The protein levels of p-AKT. (d) The nuclear expression of p65. (e) IL-6 mRNA expression in each group. The data were expressed as the (); and , compared with the control group; ^# and ^##, compared with the TNF-α group.

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