Identification of Target Genes of Antiarrhythmic Traditional Chinese Medicine Wenxin Keli

Table 1

Arrhythmia-related targets of active ingredients of WXKL.

Compound	OB	DL	Target gene
Acacetin	34.97	0.24	ADRB2
Cryptotanshinone	52.34	0.4	ADRB2/SCN5A/ADRA1D
Stigmasterol	43.83	0.76	ADRB2/ADRB1/SCN5A/CHRM2/ADRA2A
Quercetin	46.43	0.28	ADRB2/GJA1
Sitogluside	20.63	0.62	ADRB2/ADRB1/KCNH2/SCN5A/ADRA1D
β-Sitosterol	36.91	0.75	ADRB2/KCNH2/SCN5A/CHRM2
Diop	43.59	0.39	ADRB2/SCN5A
Frutinone A	65.9	0.34	ADRB2/SCN5A
Compound 1	32.16	0.41	ADRB2
DFV	32.76	0.18	ADRB2
Compound 2	71.12	0.18	KCNH2

Compound 1: 3-beta-hydroxymethylenetanshiquinone. Compound 2: (2R)-7-hydroxy-2-(4-hydroxyphenyl)chroman-4-one.