Lipid Lowering Treatment and Eligibility for PCSK9 Inhibition in Post-Myocardial Infarction Patients in Italy: Insights from Two Contemporary Nationwide Registries
Table 1
Clinical characteristics, hemodynamic and laboratory finding of patients enrolled according to baseline LDL-C levels.
Total (n. 3074)
LDL-C < 70 mg/dl (n. 1186)
LDL-C 70–99 mg/dl (n. 1150)
LDL-C ≥ 100 mg/dl (n. 738)
Age, mean ± SD
66 ± 11
66 ± 11
66 ± 11
66 ± 11
0.31
Female, (%)
584 (19.0)
195 (16.4)
222 (19.3)
167 (22.6)
0.003
Previous STEMI, (%)
1625 (52.9)
641 (54.1)
611 (53.1)
373 (50.5)
0.32
Previous NSTE-ACS, (%)
1575 (51.2)
590 (49.8)
592 (51.5)
393 (53.3)
0.32
Prior coronary revasculariz, (%)
2696 (87.7)
1089 (91.8)
1000 (87.0)
607 (82.3)
<0.0001
BMI, mean ± SD
27.4 ± 4.1
27.4 ± 4.1
27.4 ± 4.0
27.3 ± 4.2
0.89
Current smokers, (%)
609 (19.8)
205 (17.3)
216 (18.8)
188 (25.5)
<0.0001
Diabetes, (%)
841 (27.4)
371 (31.3)
293 (25.5)
177 (24.0)
0.0004
Hypertension, (%)
2369 (77.1)
943 (79.5)
869 (75.6)
557 (75.5)
0.04
History of heart failure, (%)
422 (13.7)
176 (14.8)
156 (13.6)
90 (12.2)
0.26
History of atrial fibrillation, (%)
368 (12.0)
143 (12.1)
130 (11.3)
95 (12.9)
0.59
Peripheral artery disease, (%)
222 (7.2)
79 (6.7)
93 (8.1)
50 (6.8)
0.36
History of stroke/TIA, (%)
134 (4.4)
49 (4.1)
53 (4.6)
32 (4.3)
0.85
Chronic kidney disease, (%)
360 (11.7)
162 (13.7)
118 (10.3)
80 (10.8)
0.03
Severe liver disease, (%)∗
21 (0.7)
10 (0.8)
3 (0.3)
8 (1.1)
0.07
COPD, (%)
352 (11.5)
134 (11.3)
126 (11.0)
92 (12.5)
0.59
Malignancy, (%)
144 (4.7)
52 (4.4)
60 (5.2)
32 (4.3)
0.56
SBP, mean ± SD
129 ± 17
128 ± 17
130 ± 16
130 ± 18
0.02
DBP, mean ± SD
77 ± 9
76 ± 9
77 ± 9
77 ± 10
0.12
HR, mean ± SD
66 ± 11
66 ± 11
65 ± 11
67 ± 12
0.006
Ejection fraction (%), mean ± SD
53 ± 10
53 ± 10
54 ± 10
53 ± 10
0.09
available for 2901 pts
Cholesterol (mg/dL), mean ± SD
149.9 ± 37.5
120.6 ± 20.7
149.8 ± 19.0
197.1 ± 31.2
<0.0001
available for 2917 pts
HDL-C (mg/dL), mean ± SD
45.8 ± 14.1
44.8 ± 15.3
45.9 ± 12.9
47.2 ± 13.9
<0.0001
available for 2810 pts
Triglycerides (mg/dL), mean ± SD
121.9 ± 60.9
113.5 ± 57.2
118.6 ± 54.7
140.8 ± 71.0
<0.0001
available for 2853 pts
Haemoglobin (g/dL), mean ± SD
13.7 ± 1.7
13.6 ± 1.8
13.8 ± 1.7
13.8 ± 1.6
0.0004
available for 2820 pts
Creatinine (mg/dL), mean ± SD
1.1 ± 0.5
1.1 ± 0.6
1.0 ± 0.5
1.0 ± 0.4
0.03
available for 2839 pts
eCrCl, mean ± SD
80.1 ± 26.5
79.3 ± 25.8
79.9 ± 23.8
81.7 ± 31.0
0.43
available for 2839 pts
Fasting glucose (mg/dL), mean ± SD
112.1 ± 34.8
114.4 ± 36.9
111.6 ± 33.4
109.1 ± 33.2
0.004
available for 2649 pts
STEMI, ST elevation myocardial infarction; NSTEMI, non ST elevation myocardial infarction; CS, acute coronary syndrome; TIA, transient ischemic attack; COPD, chronic obstructive pulmonary disease; SBP, systolic blood pressure; DBP, diastolic blood pressure; HR, heart rate; HDL-C, high density lipoprotein cholesterol; eCrCl, estimated creatinine clearance; ∗in presence of ascites, variceal haemorrhage and/or hepatic encephalopathy.
