Inherited Cardiac Arrhythmia Syndromes: Focus on Molecular Mechanisms Underlying TRPM4 Channelopathies

<div>Brugada syndrome ECGs. (a) Spontaneous type 1 ST-segment elevation. (b) Unmasking of ST-segment elevation by a pharmacological sodium channel blocker, pilsicainide. Under baseline condition, type 2 ST-segment elevation is recorded in lead V2. Pilsicainide injection (30 mg) unmasks type 1 electrocardiogram (ECG) in lead V2. (c) Unmasking of type 1 ECG by recordings of right precordial (V1–V2) leads at the third and second intercostal spaces. Adapted and reprinted with permission from [<a href="/journals/cdtp/2020/6615038/#B52">52</a>].</div>

Cardiovascular Therapeutics

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Figure 2: Inherited Cardiac Arrhythmia Syndromes: Focus on Molecular Mechanisms Underlying TRPM4 Channelopathies 