Review Article
Effects of Angiotensin-Converting Enzyme Inhibitors on Arterial Stiffness: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Table 1
Baseline characteristics of included studies.
| Studies | Country | Number of patients | Mean age (years) | Percentage male (%) | Baseline SBP/DBP (mmHg) | Intervention | Control | Follow-up duration | PWV type | Baseline PWV (m/s) | Jadad scale |
| London et al. [40] | France | 24 | 53.5 | 58.3 | 176.9/98.5 | Perindopril | Nitrendipine | 48 weeks | cf-PWV | 13.0 | 3 | Breithaupt-Grogler et al. [41] | Germany | 17 | 45.0–67.0 | NA | 149.9/98.3 | Cilazapril | Hydrochlorothiazide | 12 weeks | cf-PWV | 9.2 | 3 | Asmar et al. [42] | Australia | 406 | 18.0–84.0 | NA | 162.2/98.7 | Indapamide and perindopril | Atenolol | 48 weeks | cf-PWV | 12.3 | 4 | Armentano et al. [43] | Argentina | 34 | 55.0 | 64.7 | 157.0/95.0 | Ramipril | Atenolol | 12 weeks | cf-PWV | 11.7 | 4 | Komai et al. [44] | Japan | 25 | 62.1 | 64.0 | 152.0/81.9 | Cilazapril | Atenolol | 24 weeks | cf-PWV | 9.5 | 4 | London et al. [45] | Australia | 469 | 54.9 | 67.4 | 162.3/98.6 | Indapamide and perindopril | Atenolol | 48 weeks | cf-PWV | 12.7 | 4 | Anan et al. [46] | Japan | 21 | 59.0 | 47.6 | 156.5/97.0 | Perindopril | Valsartan | 40 weeks | ba-PWV | 18.3 | 3 | Ahimastos et al. [47] | Australia | 17 | 32.8 | 76.5 | 120.4/72.2 | Perindopril | Placebo | 24 weeks | cf-PWV and ba-PWV | 7.4 | 4 | Rehman et al. [48] | Malaysia | 39 | 52.8 | NA | 151.5/93.0 | Perindopril | Losartan | 24 weeks | cf-PWV | 11.5 | 3 | Morimoto et al. [49] | Japan | 32 | 64.0 | 46.9 | 145.5/82.0 | Perindopril | Amlodipine | 24 weeks | ba-PWV | 16.4 | 3 | Ahimastos et al. [50] | Australia | 40 | 66.0 | 95.0 | 139.5/87.0 | Ramipril | Placebo | 24 weeks | cf-PWV | 9.7 | 4 | Mackenzie et al. [51] | United Kingdom | 32 | 69.0 | 50.0 | 159.4/84.1 | Perindopril | Atenolol | 10 weeks | cf-PWV | 9.3 | 3 | Kostka-Jeziorny et al. [52] | Poland | 66 | 46.2 | 60.6 | 158.2/96.8 | Perindopril | Hydrochlorothiazide | 8 weeks | cf-PWV | 11.2 | 3 | Virdis et al. [53] | Italy | 50 | 45.0 | 70.0 | 148.4/92.8 | Ramipril | Aliskiren | 12 weeks | cf-PWV | 7.6 | 4 | Koumaras et al. [54] | Greece | 37 | 48.0 | 78.4 | 148.4/99.4 | Quinapril | Atenolol | 10 weeks | cf-PWV | 8.8 | 3 | Redon et al. [55] | Spain | 88 | 58.4 | 60.2 | 157.5/96.5 | Perindopril | Olmesartan | 24 weeks | ba-PWV | 9.2 | 4 | Jekell et al. [56] | Sweden | 61 | 53.6 | 65.6 | 152.5/92.9 | Ramipril | Doxazosin | 12 weeks | cf-PWV | 8.7 | 4 |
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PWV, pulse wave velocity; ba-PWV, brachial-ankle pulse wave velocity; cf-PWV, carotid-femoral pulse wave velocity; SBP, systolic blood pressure; DBP, diastolic blood pressure; NA, not available.
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