Research Article

Association between Cardiovascular Burden and Requirement of Intensive Care among Patients with Mild COVID-19

Table 2

Clinical characteristics of patients with COVID-19 with or without CV conditions.

CharacteristicAll patients ()Without CV conditions (, 85.5%)With CV conditions (, 14.5%) value

Sex
Male, (%)132 (39.8)110 (38.7)22 (45.8)0.285
Female, (%)200 (60.2)174 (61.3)26 (54.2)0.285
Age, median (IQR)51 (40-59)50 (39-59)56 (45-62)0.007

Symptoms
Fever, (%)177 (63.2)150 (63.3)27 (58.7)0.487
Cough, (%)108 (38.4)88 (37.6)20 (42.6)0.525
Fatigue, (%)39 (13.9)26 (11.1)13 (28.3)0.002
Chest tightness, (%)32 (11.5)14 (6.0)18 (40)<0.001
Diarrhea, (%)11 (3.9)9 (3.8)2 (4.3)0.873
Headache, (%)7 (2.5)5 (2.1)2 (4.3)0.323
Sore throat, (%)4 (1.4)4 (1.7)0 (0.0)1.000
Rhinorrhea, (%)4 (1.4)4 (1.7)0 (0.0)1.000
Myalgia, (%)12 (4.3)6 (2.6)6 (13.0)0.001
Toothache, (%)2 (0.6)1 (0.4)1 (2.1)0.269

Comorbidities
Diabetes, (%)11 (3.3)7 (2.5)4 (8.3)0.036
Lung disease, (%)7 (2.1)3 (1.1)4 (8.3)0.010
Radiologic abnormality,(%)201 (65.5)182 (67.2)19 (52.8)0.088

Positive SARS-CoV-2 testing by RT-PCR
Twice or more, (%)72 (23.0)60 (22.0)12 (35.1)0.147
Once, (%)241 (77.0)216 (78.0)25 (64.9)0.147

Laboratory findings
Red blood cell count (1012/L), median (IQR)4.39 (4.05-4.73)4.37 (4.04-4.68)4.49 (4.15-4.90)0.159
White cell count (109/L), median (IQR)5.25 (4.49-6.37)5.25 (4.49-6.37)5.00 (4.46-6.35)0.677
Neutrophil count (109/L), median (IQR)3.21 (2.57-4.08)3.23 (2.59-4.10)3.06 (2.53-3.91)0.468
Lymphocyte count (109/L), median (IQR)1.61 (1.26-1.91)1.58 (1.27-1.91)1.72 (1.23-1.92)0.745
NLR, median (IQR)2.06 (1.60-2.67)2.07 (1.60-2.67)2.04 (1.56-2.54)0.609
Platelet count (109/L), median (IQR)258 (216-310)263 (217-314)243 (202-287)0.085
Hemoglobin (g/L), median (IQR)135 (125-145)135 (125-145)137 (130-145)0.254

C-reactive protein
<10.00 mg/L261 (85.0)230 (85.8)31 (79.5)0.300
≥10.00 mg/L46 (15.0)38 (14.2)8 (20.5)0.300
Median length of symptom onset to admission (days) (IQR)12 (8-16)12 (8-15)14 (8-18)0.222
Median length of temporary hospital stay (days) (IQR)14 (10-19)14 (10-19)15 (8-20)0.837

Clinical outcomes
Discharge, (%)274 (82.5)249 (87.6)25 (52.1)<0.001
Require intensive care, (%)58 (17.5)35 (12.4)23 (47.9)<0.001

IQR: interquartile range; NLR: neutrophil to lymphocyte ratio.