Molecular Signatures of Human Chronic Atrial Fibrillation in Primary Mitral Regurgitation
Table 3
The most significant differentially expressed genes with their fold changes, values, and values.
Probeset ID
Gene symbol
FC RA + LA AFib vs. SR
value
value (adjusted value)
FC RA AFib vs. SR
value
value (adjusted value)
FC LA AFib vs. SR
value
value (adjusted value)
206801_at
NPPB
3.46
4.16-04
8.65-04
4.45
0.002
0.005
2.68
0.037
0.042
243737_at
ATP1B4
2.81
2.82-05
1.05-04
2.90
7.25-04
0.003
2.87
0.006
0.01
206073_at
COLQ
2.64
1.15-05
5.53-05
3.27
8.75-05
0.001
2.08
0.009
0.02
202718_at
IGFBP2
2.61
2.07-04
4.87-04
2.56
0.015
0.018
2.64
0.001
0.0072
205713_s_at
COMP
2.47
7.52-05
2.30-04
2.12
0.013
0.016
2.64
0.005
0.015
228754_at
SLC6A6
2.4
1.18-06
1.25-05
2.86
5.48-05
7.70-04
2.01
0.003
0.012
204260_at
CHGB
2.37
1.62-08
1.71-06
2.34
2.51-05
5.66-04
2.38
2.67-04
0.005
224009_x_at
DHRS9
2.24
1.72-06
1.56-05
2.44
5.29-05
7.70-04
1.99
0.011
0.021
205923_at
RELN
2.19
0.001
0.002
2.29
0.018
0.021
2.10
0.036
0.042
213001_at
ANGPTL2
2.09
6.74-08
2.13-06
2.07
3.83-06
2.00-04
2.12
0.001
0.008
201645_at
TNC
1.84
0.002
0.003
1.69
0.0284
0.031
1.94
0.046
0.046
206768_at
RPL3L
1.93
1.16-04
3.14-04
2.24
3.74-04
0.002
1.63
0.003
0.0122
205493_s_at
DPYSL4
1.9
6.23-04
0.001
1.77
0.029291
0.0314
2.04
0.008
0.018
208370_s_at
RCAN1
1.86
7.78-07
8.60-06
2.05
3.93-05
7.66-04
1.66
0.006
0.0169
225061_at
DNAJA4
1.75
6.75-07
7.85-06
2.09
3.40-07
9.95-05
229797_at
MCOLN3
-2.81
2.42-08
1.07-06
-2.43
4.71-05
7.70-04
-3.14
2.42-05
9.98-04
222927_s_at
CPLX3
-2.43
4.15-05
1.45-04
-2.94
0.002
0.005
-1.98
0.005
0.0167
205177_at
TNNI1
-2.43
3.94-04
8.28-04
-3.21
0.002
0.005
-1.86
0.027
0.0366
207344_at
AKAP3
-2.39
1.76-06
1.56-05
-1.99
0.008
0.01
-2.80
7.41-05
0.002
222919_at
TRDN
-2.12
6.09-08
2.13-06
-1.91
5.62-05
7.70-04
-2.28
5.71-04
0.0055
209693_at
ASTN2
-1.97
1.45-04
3.56-04
-2.23
0.001
0.004
-1.50
0.009
0.02
226228_at
AQP4
-1.85
6.82-05
2.18-04
-2.15
0.00180054
0.0050
-1.5
0.007
0.018
205910_s_at
CEL
-1.81
8.54-05
2.48-04
-1.99
0.003
0.006
-1.62
0.005
0.015
221288_at
GPR22
-1.78
2.56-06
2.02-05
-1.87
9.17-05
0.001
-1.66
0.007
0.018
204121_at
GADD45G
-1.75
6.56-04
0.001
-1.71
0.027
0.029
-1.82
0.009
0.0195
1559419_at
CACNB2
-1.70
6.83-04
0.001
-1.72
0.004
0.007
-1.60
0.035
0.0416
214369_s_at
RASGRP2
-1.60
1.11-07
2.87-06
-1.65
1.97-04
0.0016
-1.55
2.31-04
0.0032
209590_at
BMP7
-1.57
6.39-06
3.82-05
-1.58
7.51-04
0.0033
-1.54
8.67-04
0.0066
221796_at
NTRK2
-1.57
1.32-04
3.37-04
-2.05
9.54-07
9.95-05
213992_at
COL4A6
-1.51
0.005
0.006
-1.53
0.012
0.015
-1.53
0.022
0.032
The most significant 30 genes are chosen according to fold changes. Coexistent transcript Affy IDs in three groups of tissue types (RA + LA, RA, LA) are considered the utmost. Genes in the table were selected, the top 15 of the lists that comparison between AFib and SR () in RA + LA, RA, and LA tissues. Some Affy IDs mentioned with are not found in all three lists. However, a connection found between that gene and AFib in other studies. RA: right atrium; LA: left atrium; AFib: atrial fibrillation; SR: sinus rhythm; FC: fold change. Presented genes in alphabetical order: AKAP3: A-kinase anchoring protein 3; ANGPTL2: angiopoietin like 2; AQP4: aquaporin 4; ASTN2: astrotactin 2; ATP1B4: ATPase Na+/K+ transporting family member beta 4; BMP7: bone morphogenetic protein 7; CACNB2: calcium voltage-gated channel auxiliary subunit beta 2; CEL: carboxyl ester lipase; CHGB: chromogranin B; COL4A6: collagen type IV alpha 6 chain; COLQ: collagen like tail subunit of asymmetric acetylcholinesterase; COMP: cartilage oligomeric matrix protein; CPLX3: complexin 3; DHRS9: dehydrogenase/reductase 9; DNAJA4: DnaJ heat shock protein family (Hsp40) member A4; DPYSL4: dihydropyrimidinase like 4; GADD45G: growth arrest and DNA damage inducible gamma; GPR22: G protein-coupled receptor 22; IGFBP2: insulin like growth factor binding protein 2; MCOLN3: mucolipin TRP cation channel 3; NPPB: natriuretic peptide B; NTRK2: neurotrophic receptor tyrosine kinase 2; RASGRP2: RAS guanyl releasing protein 2; RCAN1: regulator of calcineurin 1; RELN: reelin; RPL3L: ribosomal protein L3 like; SLC6A6: solute carrier family 6 member 6; TNC: tenascin C; TNNI1: troponin I1, slow skeletal type; TRDN: triadin.
