Sodium Lactate Accelerates M2 Macrophage Polarization and Improves Cardiac Function after Myocardial Infarction in Mice

<div>Sodium lactate treatment improved cardiac performance after myocardial infarction (MI). (a) Quantitative echocardiographic analysis. EF: ejection fraction; FS: fractional shortening; LVID: s: left ventricular internal diastolic at end-systolic dimension; LV vol: s: left ventricular volume at end diastole. (b) Typical echocardiographs in each group. (c) Immunohistochemical staining of CD31 showed that sodium lactate significantly increased new vessel formation in the ischemic area. (d) TUNEL staining was performed to estimate myocardial cell apoptosis. (e) Masson trichrome staining of the heart 2 weeks after the treatments and the quantitative analysis, scale bar, 1000 <i>μ</i>m. 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Cardiovascular Therapeutics

fig1

Figure 1

Figure 1: Sodium Lactate Accelerates M2 Macrophage Polarization and Improves Cardiac Function after Myocardial Infarction in Mice 