Sodium Lactate Accelerates M2 Macrophage Polarization and Improves Cardiac Function after Myocardial Infarction in Mice

<div>Sodium lactate increased the proportion of M2 macrophages post-MI. (a) Representative images of flow cytometric analysis of myocardial F4/80+CD206+ macrophages after saline or sodium lactate treatment for 3 days post-MI. (b) Analysis of the M2 macrophage expression in each group. (c) Immunofluorescence staining of M2 macrophage markers (CD206, red) in the ischemic area. (d) Immunofluorescence staining of M2 macrophage marker (Arg-1, red) in ischemic myocardial tissue. (e) Western blot analysis showed the expression of M2 macrophage marker Arg-1 after lactate or saline treatment post-MI. 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Cardiovascular Therapeutics

fig2

Figure 2

Figure 2: Sodium Lactate Accelerates M2 Macrophage Polarization and Improves Cardiac Function after Myocardial Infarction in Mice 