Research Article
Ginkgolide B Protects Cardiomyocytes from Angiotensin II-Induced Hypertrophy via Regulation of Autophagy through SIRT1-FoxO1
Figure 4
SIRT1 mediates the protective effects of Ginkgolide B on Ang II-induced hypertrophy in cardiomyocytes. H9c2 cells were pretreated with Ginkgolide B (30 μM) and SIRT1 inhibitor, EX-527 (100 nM), for 2 h and then incubated with Ang II (1 μM) for further 48 h. (a) ANP mRNA level after SIRT1 inhibition. (b) Representative blots of SIRT1 and autophagy-related proteins. EX-527 abolishes Ginkgolide B’s promotive effect on (c) FoxO1 and (d) Beclin-1 protein expressions. , vs. the GB group; ### vs. the EX-527 group.
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