Remote and Anesthetic-Induced Myocardial Preconditioning Is Preserved in Atherosclerotic LDL Receptor-/- Mice In Vivo

Figure 1

Study protocol and time line. CON WT: control group (C57/BL6 wild type) no preconditioning; MEM15: memory phase over 15 minutes; CAO45: coronary artery occlusion over 45 minutes; REP60, 120, and 180: reperfusion phase 60, 120, and 180 minutes after COA45; RIPC WT: remote ischemic preconditioning group (C57/BL6 WT); APC WT: anesthetic-induced preconditioning group (C57/BL6 wild type); CON LDLR-/-: control group (C57/BL6 LDL-receptor deficiency); RIPC LDLR-/-: remote ischemic preconditioning group (C57/BL6 LDL-receptor deficiency); APC LDLR-/-: anesthetic induce preconditioning group (C57/BL6 LDL-receptor deficiency). At the end of REP180, the mouse was sacrificed and the heart was isolated.