Myocardial Infarction and AGT p.Thr174Met Polymorphism: A Meta-Analysis of 7657 Subjects

Table 1

Characteristics of the selected studies of the association between AGT p.Thr174Met polymorphism and myocardial infarction.

Author	Year	Region	Ethnicity	MI			Control			Minor allele frequency		Genotyping	Matching criteria	Sample size (MI/control)	value for HWE	NOS score (stars)
				TT	TM	MM	TT	TM	MM	MI	Control
Tiret et al. [18]	1995	UK, France	Caucasian	493	125	12	578	154	9	0.118	0.116	AS-PCR	BMI, ethnicity	630/741	0.73	6
Frossard et al. [28]	1998	UAE	Asian	8	18	14	19	26	16	0.1	0.11	PCR-RFLP	Age, sex, BMI, ethnicity	40/61	0.26	6
Chistiakov et al. [23]	1999	Russia	Caucasian	26	17	2	48	11	1	0.322	0.108	PCR-RFLP	Ethnicity	45/60	0.69	6
Gardemann et al. [24]	1999	Germany	Caucasian	817	228	13	925	249	18	0.120	0.120	PCR	Age, ethnicity	1058/1192	0.79	6
Liu et al. [25]	2002	China	Asian	48	9	1	73	17	0	0.095	0.094	PCR	Sex, ethnicity	58/90	0.32	6
Renner et al. [26]	2005	Austria	Caucasian	1017	325	28	545	174	14	0.139	0.138	PCR	BMI, ethnicity	1370/733	0.98	6
Ning et al. [16]	2006	China	Asian	84	20	10	168	33	3	0.175	0.096	PCR-RFLP	Ethnicity	114/204	0.36	6
Sun et al. [27]	2006	China	Asian	84	18	10	105	21	2	0.170	0.098	PCR	Age, sex, BMI, ethnicity	112/128	0.43	6
Xie et al. [17]	2008	China	Asian	122	30	23	127	34	6	0.217	0.153	PCR-RFLP	Age, sex, ethnicity	175/167	0.06	6
Konopka et al. [29]	2011	Poland	Caucasians	54	41	5	67	27	1	0.255	0.153	PCR-RFLP	Sex, ethnicity	100/95	0.34	6
Isordia-Salas et al. [30]	2018	Mexico	Caucasians	187	53	2	202	39	1	0.118	0.085	PCR-RFLP	Age, sex, BMI, ethnicity	242/242	0.54	6

Case-control study design was used in all studies. AS-PCR: allele-specific PCR; BMI: body mass index; MI: myocardial infarction; PCR: polymerase chain reaction; RFLP: restriction fragment length polymorphism; TT: ThrThr; TM: ThrMet; MM: MetMet; UAE: United Arab Emirates; UK: United Kingdom.