Myocardial Infarction and AGT p.Thr174Met Polymorphism: A Meta-Analysis of 7657 Subjects
Table 2
Summary results of meta-analysis on association between AGT p.Thr174Met polymorphism and myocardial infarction.
Genetic model
Pooled OR (95% CI)
value
value
Studies
Sample size
()
MI
Control
Recessive
Overall group
2.26 (1.35-3.77)
3.11
0.002
11
3944
3713
0.03 (49%)
Asian subgroup
4.08 (2.35-7.09)
5.00
5
499
650
0.58 (0%)
Caucasian subgroup
1.18 (0.79-1.76)
0.80
0.42
6
3445
3063
0.54 (0%)
Dominant
Overall group
1.131 (1.016-1.260)
2.25
0.024
11
3944
3713
0.058 (44.0%)
Asian subgroup
1.444 (1.092-1.910)
2.58
0.010
5
499
650
0.786 (0%)
Caucasian subgroup
1.085 (0.966-1.219)
0.96
0.338
6
3445
3063
0.027 (60.5%)
Codominant
Overall group
2.198 (1.334-3.621)
3.09
0.002
11
3944
3713
0.051 (45.1%)
Asian subgroup
3.928 (2.222-6.945)
4.70
5
499
650
0.685 (0%)
Caucasian subgroup
1.195 (0.799-1.788)
0.87
0.386
6
3445
3063
0.442 (0%)
Additive
Overall group
1.363 (1.132-1.641)
3.26
0.001
11
3944
3713
0.002 (63.5%)
Asian subgroup
1.701 (1.350-2.143)
4.51
5
499
650
0.642 (0%)
Caucasian subgroup
1.185 (0.976-1.438)
1.71
0.087
6
3445
3063
0.027 (60.5%)
,; CI: confidence interval; OR: odds ratio; MI: myocardial infarction; recessive genetic model: MM vs. TM+TT; dominant genetic model: TM+MM vs. TT; codominant genetic model: MM vs. TT; additive genetic model: total M vs. total T.
