Wogonin Inhibits Cardiac Hypertrophy by Activating Nrf-2-Mediated Antioxidant Responses

Figure 1

Wog prevented AngII-induced cardiomyocyte hypertrophy. H9C2 cells were pretreated with Wog (20 μM) for 2 hours and then incubated with AngII (1 μM) for the times indicated. (a) H9C2 cells were treated with Wog at the indicated concentrations for 48 h, and the potential effect of Wog treatment was assessed using the CCK8 cell viability assay (); (b, c) Western blot analysis of MyHC-β in H9C2 cells (); (d, e) representative images of rhodamine-labeled phalloidin staining from H9C2 cells (magnification: ×200, scale bar: 20 μm). , , and compared to Ctrl; , , and compared to AngII.

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