Thymosin β4 Protects against Cardiac Damage and Subsequent Cardiac Fibrosis in Mice with Myocardial Infarction

Figure 6

H₂O₂ increases MMP and ROS and activates inflammatory responses in myocytes. Detection of MMP (a, c) and cellular oxidative stress (b, d) in H₂O₂ (0-400 μM, 4 h) treated myocytes. Secretion of IL-1β in myocytes treated by H₂O₂ (0-400 μM, 4 h) (e), secretion of IL-1β in myocytes treated by H₂O₂ (400 μM, 4 h) together with NAC (10 mM) (f), FCCP (10 μM) or oligomycin (10 μM) (g). Western blot revealed the expression of PINK1 and Tom40 in myocytes treated by H₂O₂ (0-400 μM) (h).

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