HSPB1 Regulates Autophagy and Apoptosis in Vascular Smooth Muscle Cells in Arteriosclerosis Obliterans

Figure 5

Schematic illustrating the working principle of HSPB1-related signaling in VSMCs. We propose that HSPB1 maintains the phosphorylation state of JNK, thereby activating Beclin-1-dependent autophagy associated with atherosclerosis. Additionally, HSPB1 plays an important role in VSMC apoptosis.