Apolipoprotein A1-Related Proteins and Reverse Cholesterol Transport in Antiatherosclerosis Therapy: Recent Progress and Future Perspectives

Table 1

Animal models exploring the role of the LCAT gene in cholesterol metabolism.

Animal	Model	Construction	LCAT gene	LCAT activity	HDL-C concentration	AS	Reference
Mice	Transgenic	—	Overexpressed	↑	↑	↑	[60]
Mice	Transgenic	LCAT-Tg was hybridized with CETP-Tg mice	Overexpressed	↑	↑	↓	[61]
Mice	—	LCAT defective type	Knockout	↓	↓	↓	[62]
Hamster	—	LCAT gene mutation	Loss	Loss	↓	↓	[63]
Rabbits	Transgenic	Genomic hLCAT with its own promoter and 3-flank	Overexpressed	↑	↑	↓	[64]
Squirrel monkey	Virus infection	hLCAT in adenoviruses	Overexpressed	↑	↑	↓	(65)