Colchicine Does Not Reduce Abdominal Aortic Aneurysm Growth in a Mouse Model

Figure 1

The effect of E-BAPN on infrarenal aortic diameter and structure. (a) IRA diameter in mice receiving E-BAPN and sham controls measured by ultrasound and AAA growth was assessed using linear mixed model analysis. Data were log transformed during statistical analysis to conform to model assumptions; however, raw values are shown. (b) Maximum IRA diameter in mice receiving E-BAPN and sham controls measured ex vivo at the experimental endpoint. Data were assessed as normally distributed and were analysed using unpaired two-tailed -tests and presented in box plots. The box indicates the range between 1^st and 3^rd interquartile range. The whiskers indicate the minimum and maximum values. (c) Percentage of mice with different severity of aneurysm. I, no aneurysm; II, aortas between 150 and 300% of nondiseased controls; III, >300% of nondiseased controls. Data was analysed using Fischer’s exact test. (d) Percentage of mice with different severity of aortic elastin degradation. I, no elastin degradation; II, mild fragmentation or damage; III, moderate damage; IV, severe fragmentation with sections of complete destruction of all elastic lamellae. Data were analysed using Fischer’s exact test. Mice receiving E-BAPN had significantly higher AAA growth over 80 days (; ) and significantly higher aneurysm presence (). E-BAPN and sham on day 90. E-BAPN: elastase and 3-aminopropionitrile; IRA: infrarenal aorta.

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