Colchicine Does Not Reduce Abdominal Aortic Aneurysm Growth in a Mouse Model

Figure 2

The effect of E-BAPN administration on gene expression and pathway regulation. (a) GSEA enrichment map showing pathways that are upregulated and downregulated in mice receiving E-BAPN compared with sham controls (). Red circles indicate upregulated pathways, and blue circles indicate downregulated pathways in mice receiving E-BAPN compared with sham controls. Circle size indicates the size of the gene set, and darker shades of red or blue indicate higher normalised enrichment score indicating more substantial pathway activation. Blue lines indicate overlap of differentially expressed genes involved in specific pathways. E-BAPN: elastase and 3-amniopropionitrile; GSEA: Gene Set Enrichment Analysis; ECM: extracellular matrix; GPCR: G-protein coupled receptor; JAK-STAT: Janus kinase-signal transducer and activator of transcription; MAPK: mitogen-activated protein kinase; PI3K: phosphoinositide 3-kinase; PKB: protein kinase B.