Colchicine Does Not Reduce Abdominal Aortic Aneurysm Growth in a Mouse Model

Figure 4

The effect of oral colchicine administration on AAA incidence, severity, and rupture rates. (a) Maximum IRA diameter measured by ultrasound and analysed using linear mixed effects modeling. Data were log transformed during statistical analysis to conform to model assumptions; however, raw values are shown. (b) Maximum diameter of the IRA as measured by morphometry at the end of the experiment (day 90). Data were assessed as normally distributed and were analysed using unpaired two-tailed -tests and presented in box plots. The box indicates the range between 1^st and 3^rd interquartile range. The whiskers indicate the minimum and maximum values. (c) Percentage of mice with different severity of AAA. I, no aneurysm; II, 150-300% normal diameter; III, >300% normal diameter. Data were analysed using Fischer’s exact test. (d) Percentage of mice with different severity of elastin degradation. I, no elastin degradation; II, mild fragmentation or damage; III, moderate damage; IV, severe fragmentation with sections of complete destruction of all elastic lamellae. Data was analysed using Fischer’s exact test. (e) Percentage of mice free from aneurysm rupture using Kaplan-Meier’s survival curve analysed using log-rank test. (f) Percentage of mice with and without ILT. Data were analysed using Fischer’s exact test. Control and colchicine at day 90. IRA: infrarenal aorta.

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