Cardiovascular Therapeutics

Research Article

The Rate of Clinical Outcomes in Atrial Fibrillation according to Antithrombotic Strategy: The COOL-AF Registry

Table 1

Baseline characteristics of atrial fibrillation patients compared among the 3 different antithrombotic regimens.


Variables	All ()	OAC alone ()	OAC+antiplatelet ()	Antiplatelet alone ()	value

Age (years)					0.018^c
Female gender	1,322 (42.3%)	1,017 (45.0%)	97 (31.5%)	218 (37.5%)	<0.001^a,b
Time after AF diagnosis (yrs)					0.159
Atrial fibrillation					<0.001^a,b
(i) Paroxysmal	998 (31.7%)	657 (29.1%)	121 (39.3%)	220 (37.8%)
(ii) Persistent	603 (19.2%)	406 (18.0%)	75 (24.4%)	122 (21.0%)
(iii) Permanent	1,547 (49.1%)	1,195 (52.9%)	112 (36.4%)	240 (41.2%)
Symptomatic AF	2,421 (76.9%)	1,751 (77.5%)	222 (72.1%)	448 (77.0%)	0.102
History of heart failure	866 (27.5%)	578 (25.6%)	123 (39.9%)	165 (28.4%)	<0.001^a,c
History of CAD	540 (17.2%)	227 (10.1%)	189 (61.4%)	124 (21.3%)	<0.001^a,b,c
CIED	323 (10.3%)	224 (9.9%)	46 (14.9%)	53 (9.1%)	0.015^a,c
History of ischemic stroke/TIA	578 (18.4%)	477 (21.1%)	61 (19.8%)	40 (6.9%)	<0.001^b,c
Hypertension	2,232 (70.9%)	1,619 (71.7%)	242 (78.6%)	371 (63.7%)	<0.001^a,b,c
Diabetes mellitus	819 (26.0%)	564 (25.0%)	126 (40.9%)	129 (22.2%)	<0.001^a,c
Smoking	618 (19.6%)	383 (17.0%)	90 (29.2%)	145 (24.9%)	<0.001^a,b
Dyslipidemia	1,822 (57.9%)	1,278 (56.6%)	228 (74.0%)	316 (54.3%)	<0.001^a,c
Renal replacement therapy	38 (1.2%)	14 (0.6%)	8 (2.6%)	16 (2.7%)	<0.001^a,b
Dementia	29 (0.9%)	19 (0.8%)	6 (1.9%)	4 (0.7%)	0.131
History of bleeding	308 (9.8%)	225 (10.0%)	47 (15.3%)	36 (6.2%)	<0.001^a,b,c
History of PAD	41 (1.3%)	20 (0.9%)	12 (3.9%)	9 (1.5%)	<0.001^a
CHA₂DS₂-VASc score					<0.001^a,b,c
(i) 0	108 (3.4%)	60 (2.7%)	1 (0.3%)	47 (8.1%)
(ii) 1	357 (11.3%)	215 (9.5%)	21 (6.8%)	121 (20.8%)
(iii) ≥2	2,683 (85.2%)	1,983 (87.8%)	286 (92.9%)	414 (71.1%)
HAS-BLED score					<0.001^a,b,c
(i) 0	344 (10.9%)	334 (14.8%)	2 (0.6%)	8 (1.4%)
(ii) 1-2	2,276 (72.3%)	1,657 (73.4%)	160 (51.9%)	459 (78.9%)
(iii) ≥3	528 (16.8%)	267 (11.8%)	146 (47.4%)	115 (19.8%)

Data presented as or number and percentage. Abbreviations: OAC: oral anticoagulant; AF: atrial fibrillation; CAD: coronary artery disease; CIED: cardiac implantable electronic device; TIA: transient ischemic attack; PAD: peripheral arterial disease. ^aStatistically significant () OAC alone vs. OAC+antiplatelet. ^bStatistically significant () OAC alone vs. antiplatelet alone. ^cStatistically significant () OAC+antiplatelet vs. antiplatelet alone.