The Rate of Clinical Outcomes in Atrial Fibrillation according to Antithrombotic Strategy: The COOL-AF Registry

Table 2

Clinical outcome events per 100 person-years and absolute 2-year risk compared among antithrombotic regimens for each clinical outcome.

Regimens	Patients	Events	100 person-years	Rate per 100 person-years (95% CI)	Absolute 2-year risk (95% CI) (death as competing risk)
Ischemic stroke/TIA
OAC alone	2,258	59	46.4	1.27 (0.97-1.64)	2.49 (1.90-3.21)
OAC+antiplatelet	308	11	7.2	1.53 (0.76-2.73)	3.30 (2.58-4.15)
Antiplatelet alone	582	29	12.9	2.25 (1.51-3.23)	4.35 (2.93-6.18)
Major bleeding
OAC alone	2,258	110	46.4	2.37 (1.95-2.86)	5.05 (4.14-6.08)
OAC+antiplatelet	308	23	7.2	3.19 (2.03-4.79)	4.20 (3.38-5.15)
Antiplatelet alone	582	19	12.9	1.47 (0.89-2.30)	3.49 (2.37-4.94)
Death
OAC alone	2,258	167	46.4	3.60 (3.07-4.19)
OAC+antiplatelet	308	39	7.2	5.41 (3.85-7.40)
Antiplatelet alone	582	53	12.9	4.11 (3.08-5.37)

Abbreviations: CI: confidence interval; TIA: transient ischemic attack; OAC: oral anticoagulant.