Cardiovascular Therapeutics

Research Article

Vascular Closure Devices versus Manual Compression in Cardiac Interventional Procedures: Systematic Review and Meta-Analysis

Table 3

Results of meta-regression analysis for outcome indicators.


Variable	Slope coefficient	Standard error	value	value	95% CI
Variable	Slope coefficient	Standard error	value	value	Lower limit	Upper limit

Total vascular complication
Publication year	− 0.0038882	0.0366959	− 0.11	0.916	− 0.0796248	0.0718485
Research country	0.2122738	0.1532003	1.39	0.179	− 0.1039161	0.5284636
Study design	0.1899589	0.3187227	0.6	0.557	− 0.4678523	0.8477701
Operation type	− 0.1619395	0.170639	− 0.95	0.352	− 0.5141212	0.1902422
VCD type	− 0.0748574	0.1508855	− 0.5	0.624	− 0.3862698	0.2365551
Diagnosis or treatment	0.0898802	0.2147782	0.42	0.679	− 0.3534002	0.5331606
Vascular access site	0.0477251	0.2622489	0.18	0.857	− 0.4935301	0.5889803
Major vascular complication
Publication year	0.0134347	0.0294913	0.46	0.653	− 0.0478958	0.0747652
Research country	0.1285218	0.0682783	1.88	0.074	− 0.0134707	0.2705144
Study design	0.0534072	0.1441656	0.37	0.715	− 0.2464016	0.353216
Operation type	− 0.2259866	0.1351589	− 1.67	0.109	− 0.5070649	0.0550916
VCD type	0.0388801	0.1573338	0.25	0.807	− 0.2883134	0.3660736
Diagnosis or treatment	0.2951529	0.2025009	1.46	0.160	− 0.1259707	0.7162765
Vascular access site	− 0.1544536	0.2936646	− 0.53	0.604	− 0.7651627	0.4562555
Bleeding-related complication
Publication year	0.0071636	0.0433535	0.17	0.870	− 0.0825199	0.0968471
Research country	− 0.0502883	0.2334795	− 0.22	0.831	− 0.5332774	0.4327009
Study design	0.3204116	0.1969521	1.63	0.117	− 0.087015	0.7278381
Operation type	− 0.3396131	0.1908548	− 1.78	0.088	− 0.7344263	0.0552
VCD type	− 0.2991253	0.2131044	− 1.4	0.174	− 0.7399653	0.1417147
Diagnosis or treatment	0.1150813	0.2458099	0.47	0.644	− 0.3934151	0.6235778
Vascular access site	− 0.2120466	0.290403	− 0.73	0.473	− 0.8127909	0.3886977
TTH
Publication year	− 0.4921285	0.3435058	− 1.43	0.195	− 1.304391	0.3201336
Research country	− 5.162946	3.383787	− 1.53	0.171	− 13.16433	2.83844
Study design	0.5445317	2.421016	0.22	0.828	− 5.180262	6.269325
Operation type	1.148615	1.776338	0.65	0.538	− 3.051757	5.348986
VCD type	− 4.169431	3.268597	− 1.28	0.243	− 11.89843	3.559573
Diagnosis or treatment	1.495201	2.149798	0.7	0.509	− 3.588264	6.578666
Vascular access site	− 0.6847343	4.187115	− 0.16	0.875	− 10.58569	9.216219
TTA
Publication year	− 0.3388484	0.2746872	− 1.23	0.343	− 1.520732	0.8430351
Research country	− 1.871418	4.513303	− 0.41	0.719	− 21.2906	17.54776
Study design	− 6.795713	1.759985	− 3.86	0.061	− 14.36832	0.7768918
Operation type	− 2.313697	2.0215	− 1.14	0.371	− 11.01151	6.384116
VCD type	− 6.795713	1.759985	− 3.86	0.061	− 14.36832	0.7768922
Diagnosis or treatment	− 2.478133	1.655155	− 1.5	0.273	− 9.599688	4.643422
Vascular access site	2.048284	2.764677	0.74	0.536	− 9.847159	13.94373
TTD
Publication year	0.0616289	0.6462428	0.1	0.939	− 8.149665	8.272922
Research country	− 0.3444556	3.792939	− 0.09	0.942	− 48.53832	47.84941
Study design	− 0.1481234	1.674416	− 0.09	0.944	− 21.4236	21.12736
Operation type	− 10.58069	11.3521	− 0.93	0.522	− 154.8228	133.6614
VCD type	− 4.791256	5.455508	− 0.88	0.541	− 74.11005	64.52754
Diagnosis or treatment	− 9.694279	11.71157	− 0.83	0.560	− 158.5038	139.1153
Vascular access site	1.529658	5.465324	0.28	0.826	− 67.91387	70.97318
Patient-reported outcome
Publication year	− 25.04569	23.21049	− 1.08	0.476	− 319.963	269.8716
VCD type	− 38.13615	38.23929	− 1	0.501	− 524.0125	447.7402
Vascular access site	− 172.319	97.29436	− 1.77	0.327	− 1408.561	1063.923

Stata suggested that colinearity between covariate study design and VCD type. Some covariates were not included in this meta-regression analysis because sensitivity analysis had been performed.