Bioinformatics and System Biological Approaches for the Identification of Genetic Risk Factors in the Progression of Cardiovascular Disease

Table 3

The 10 most significant hub proteins.

Protein	Description	Associated risk factor
FPR2	Formyl peptide receptor 2	Upregulated for HTN
TNF	Tumor necrosis factor	Upregulated for HTN
CXCL8	C-X-C motif chemokine ligand 8	Upregulated for aging
CXCL1	C-X-C motif chemokine ligand 1	Upregulated for HTN
IL1B	Interleukin 1 beta	Upregulated for HTN
VEGFA	Vascular endothelial growth factor A	Upregulated for obesity
CYBB	Cytochrome B-245 beta chain	Upregulated for aging
PTGS2	Prostaglandin-endoperoxide synthase 2	Upregulated for HTN
ITGAX	Integrin subunit alpha X	Upregulated for aging
CCR5	C-C motif chemokine receptor 5	Downregulated for HTN