Bioinformatics and System Biological Approaches for the Identification of Genetic Risk Factors in the Progression of Cardiovascular Disease

Table 4

Significant functional pathways of CVD are also associated in its risk factors.

ID	Pathway	Genes in pathway	Risk factors	value
hsa05418	Fluid shear stress and atherosclerosis	THBD, FOS, MAP2K5, VEGFA, IL1B, TNF, and ICAM1	Obesity, HTN	1.43E-03
hsa04260	Cardiac muscle contraction	ATP1A2, SLC8A1	HCL	1.95E-02
hsa05323	Rheumatoid arthritis	TGFB2, FOS, VEGFA, TGFB2, CXCL8, CCL20, CXCL1, IL1B, CXCL1, TNF, TLR4, and ICAM1	Obesity, HTN, and aging	4E-03
hsa04060	Cytokine-cytokine receptor interaction	IL1RN, CCL20, TNFRSF21, IL1B, ACKR3, CXCL1, CCR5, IL6ST, TNF, CCL13, TGFB2, CXCL8, CCL20, ACKR3, and CXCL1	T2D, HTN, aging	1.83E-03
hsa04668	TNF signaling pathway	NFKBIA, IL1B, CXCL1, PTGS2, TNF, and ICAM1	HTN	2.86E-08
hsa04657	IL-17 signaling pathway	CXCL8, CCL20, CXCL1, NFKBIA, IL1B, CXCL1, PTGS2, and TNF	Aging, HTN	4.88E-07
hsa04062	Chemokine signaling pathway	CCL13, CXCL8, CCL20, CXCL1, NFKBIA, CXCL1, and CCR5	Aging, HTN	4.06E-03
hsa04350	TGF-beta signaling pathway	TGFB2, THBS1	Obesity	3.96E-02
hsa04010	MAPK signaling pathway	TGFB2, FOS, VEGFA, DUSP1, and AREG	Obesity, aging	3.51E-02
hsa04064	NF-kappa B signaling pathway	CCL13, CXCL8, BCL2A1, PLAU, NFKBIA, BCL2A1, IL1B, PTGS2, TNF, TLR4, and ICAM1	Aging, HTN	1.05E-03
hsa04933	AGE-RAGE signaling pathway	THBD, TGFB2, COL3A1, VEGFA, THBD, IL1B, TNF, and ICAM1	Obesity, HTN	4.19E-04
hsa04151	PI3K-Akt signaling pathway	LAMA4, IL2RA, MDM2, THBS1, and VEGFA	Obesity	7.98E-03