Cardiovascular Therapeutics

Research Article

Bioinformatics and System Biological Approaches for the Identification of Genetic Risk Factors in the Progression of Cardiovascular Disease

Table 5

Significant ontological pathways of CVD are also associated in its risk factors.
GO IDPathwayGenes in pathwayRisk factors value
GO:0042310VasoconstrictionADRA1A, SLC8A1HCL, HTN2.02E-02
GO:0014829Vascular smooth muscle contractionSLC8A1HCL1.9E-02
GO:0030194Positive regulation of blood coagulationTHBD, TLR4, and THBS1Obesity, HTN4.71E-04
GO:0045823Positive regulation of heart contractionADM, ADRA1A, and TGFB2HTN, aging, and obesity4.71E-04
GO:0035051Cardiomyocyte differentiationTGFB2, NRG1Aging1.64E-03
GO:0070508Cholesterol importAPOA1Aging2.78E-02
GO:0006954Inflammatory responseCCL20, NFAM1, TNFRSF21, MMP25, IL2RA, PTGER3, FOS, LYZ, THBS1, IL1B, CXCL1, FPR2, TNF, and TLR4T2D, obesity, and HTN6.30E-05
GO:0045765Regulation of angiogenesisTGFB2, PTGIS, THBS1, GTF2I, VEGFA, PTGIS, PRKD1, PML, IL1B, and CYP1B1Obesity, HCL, HTN, and obesity3.90E-04
GO:0070486Leukocyte aggregationIL1BHTN1.18E-02
GO:0032722Positive regulation of chemokine productionIL1B, TNF, and TLR4HTN2.59E-05
GO:0043410Positive regulation of MAPK cascadeCCL13, TGFB2, CCL20, ACKR3, S100A12, ACKR3, FPR2, TNF, and ADRA1AHTN, aging1.22E-03