Silencing RNA for MMPs May Be Utilized for Cardioprotection

Figure 2

MMP-2 gene expression (a), concentration (b), and activity (c) in heart homogenates and MMP-9 gene expression (d), concentration (e), and activity (f) in the heart tissue. Representative zymogram of MMP-2/MMP-9 activity in heart homogenates (HT10-80 and PRP were used as standards for pro-/active MMP-2 and MMP-9) (g). Graph presenting the site of siRNA binding to the fragment of MMP-9 mRNA sequence (h). Aero: aerobic control group; I/R: ischemia/reperfusion; MMP-2: matrix metalloproteinase 2; MMP-9: matrix metalloproteinase 9; PRP: platelet-rich plasma.

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