Silencing RNA for MMPs May Be Utilized for Cardioprotection

Figure 3

An influence of MMP-2 siRNA on heart function: heart rate (a). RPP calculated as the product of the heart rate and left ventricular developed pressure (heart rate x left ventricular developed pressure/1000) (b). Recovery of heart mechanical function (difference between RPP at 25^th and 77^th min of perfusion expressed as a percentage of RPP recovery) (c). Correlation between heart mechanical function recovery, heart rate and MMP-2 activity (d); MMP-9 activity (e) in heart homogenates; straight line: standard curve; dotted line: 95% confidence band. Aero: aerobic control group; bpm: beats per minute; HR: heart rate; I/R: ischemia-reperfusion group; MMP-2: matrix metalloproteinase 2; MMP-9: matrix metalloproteinase 9; RPP: rate pressure product. , ; ; ; ; . vs. Aero, ^# vs. I/R, and ^$ vs. I/R+scrRNA.

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