Cardiovascular Therapeutics

Research Article

Silencing RNA for MMPs May Be Utilized for Cardioprotection

Table 1

An influence of MMP-2 siRNA on heart rate, LVDP, coronary flow, and recovery of heart functions of isolated rat hearts.


Parameter	Groups					value^d
Parameter	Aero	Aero+MMP-2 siRNA and siPORT	I/R	I/R+scr RNA	I/R+MMP-2 siRNA and siPORT	value^d

HR (bpm)^a					^#$	<0.01
LVDP (mmHg)^a					^#$	<0.01
CF (mL/min)^b					^#$	<0.01
Recovery of RPP (%)^c					^#$	<0.001

. ^aAfter I/R (77^th minute of the experiment). ^bAfter ischemia (47^th minute: first minute of reperfusion). ^cDifference between RPP in 25^th and 77^th minutes of experiment. ^dANOVA test; vs. aerobic; ^# vs. I/R, $ vs. I/R+scrRNA. Aero: aerobic control group; CF: coronary flow; HR: heart rate; I/R: ischemia-reperfusion group; LVDP: left ventricular developed pressure; MMP-2: matrix metalloproteinase 2; RPP: rate pressure product.