Brain Aging in the Oldest-Old

Table 2

Alzheimer’s disease pathology in the oldest-old with versus without cognitive impairment.

	Cognitively intact oldest-old subjects	Cognitively impaired oldest-old subjects
Senile plaques	Similar lesion load	Similar lesion load
	Overall, poor correlation with clinical status
	No or little invasion of anterior CA1 field	Invasion of anterior CA1 field
	Similar density in posterior CA1field	Similar density in posterior CA1 field
Neurofibrillary tangles	Similar, mild invasion of EC	Similar, mild invasion of EC (controversial)
	Possibly less neuritic dystrophy	Possibly more neuritic dystrophy
	Overall, poor correlation with clinical status
Neurones	Similar neurone counts	Similar neurone counts
	Overall, poor correlation with clinical status

CA: Cornu Ammonis; EC: entorhinal cortex.