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Current Gerontology and Geriatrics Research
Volume 2010 (2010), Article ID 381637, 13 pages
Research Article

Dynamic Determinants of Longevity and Exceptional Health

1Center for Population Health and Aging, Duke University, Durham, NC 27708, USA
2Duke Comprehensive Cancer Center, Durham, NC 27705, USA

Received 27 April 2010; Revised 12 July 2010; Accepted 1 September 2010

Academic Editor: Donald Craig Willcox

Copyright © 2010 Anatoli I. Yashin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


It is well known from epidemiology that values of indices describing physiological state in a given age may influence human morbidity and mortality risks. Studies of connection between aging and life span suggest a possibility that dynamic properties of age trajectories of the physiological indices could also be important contributors to morbidity and mortality risks. In this paper we use data on longitudinal changes in body mass index, diastolic blood pressure, pulse pressure, pulse rate, blood glucose, hematocrit, and serum cholesterol in the Framingham Heart Study participants, to investigate this possibility in depth. We found that some of the variables describing individual dynamics of the age-associated changes in physiological indices influence human longevity and exceptional health more substantially than the variables describing physiological state. These newly identified variables are promising targets for prevention aiming to postpone onsets of common elderly diseases and increase longevity.