Acquired Haemophilia A in the Elderly: Case Reports

Table 3

Diagnostic tests in AHA in the elderly (see Huth-Kuhne et al., modified [5]).

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(1) Mixing test: prolongation of the aPTT in a mixture of

 patient and normal plasma after 1-2 h incubation

 compared to an immediate mix is typical of FVIII

 autoantibodies.

(2) Clotting factor measurement: patients should have FVIII,

 IX, X, XI, XII levels measured; an isolated low FVIII level

 is suggestive of AHA.

(3) Quantification of the inhibitor titer: Bethesda assay, the test

 should be repeated to confirm the presence of the inhibitor.

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