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Current Gerontology and Geriatrics Research
Volume 2011, Article ID 979270, 8 pages
http://dx.doi.org/10.1155/2011/979270
Clinical Study

Potential Explanatory Factors for Higher Incident Hip Fracture Risk in Older Diabetic Adults

1Department of Epidemiology, Center for Aging and Population Health, University of Pittsburgh, 130 North Bellefield Avenue, Room 515, Pittsburgh, PA 15213, USA
2Group Health Research Institute, Seattle, WA 98101-2900, USA
3Department of Medicine, University of California, Davis, CA 95817, USA
4VA Pittsburgh Healthcare System and Renal-Electrolyte Division, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15240, USA
5The Cardiovascular Health Research Unit, Departments of Medicine and Epidemiology, University of Washington, Seattle, WA 98101, USA
6Laboratory of Epidemiology, Demography and Biometry, Intramural Research Program, National Institute on Aging, Bethesda, MD 20892, USA
7Division of Geriatric Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA

Received 23 December 2010; Revised 22 March 2011; Accepted 24 May 2011

Academic Editor: Richard Crilly

Copyright © 2011 Elsa S. Strotmeyer et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. P. Vestergaard, “Discrepancies in bone mineral density and fracture risk in patients with type 1 and type 2 diabetes—a meta-analysis,” Osteoporosis International, vol. 18, no. 4, pp. 427–444, 2007. View at Publisher · View at Google Scholar · View at Scopus
  2. M. Janghorbani, R. M. Van Dam, W. C. Willett, and F. B. Hu, “Systematic review of type 1 and type 2 diabetes mellitus and risk of fracture,” American Journal of Epidemiology, vol. 166, no. 5, pp. 495–505, 2007. View at Publisher · View at Google Scholar · View at Scopus
  3. L. A. Ahmed, R. M. Joakimsen, G. K. Berntsen, V. Fønnebø, and H. Schirmer, “Diabetes mellitus and the risk of non-vertebral fractures: the Tromso study,” Osteoporosis International, vol. 17, no. 5, pp. 495–500, 2006. View at Publisher · View at Google Scholar
  4. M. Janghorbani, D. Feskanich, W. C. Willett, and F. Hu, “Prospective study of diabetes and risk of hip fracture: the nurses' health study,” Diabetes Care, vol. 29, no. 7, pp. 1573–1578, 2006. View at Publisher · View at Google Scholar · View at Scopus
  5. A. H. Holmberg, O. Johnell, P. M. Nilsson, J. Nilsson, G. Berglund, and K. Åkesson, “Risk factors for fragility fracture in middle age. A prospective population-based study of 33,000 men and women,” Osteoporosis International, vol. 17, no. 7, pp. 1065–1077, 2006. View at Publisher · View at Google Scholar
  6. A. H. Holmberg, O. Johnell, J. Nilsson, K. Åkesson, P. M. Nilsson, and G. Berglund, “Erratum to "Risk factors for fragility fracture in middle age. A prospective population-based study of 33,000 men and women",” Osteoporosis International, vol. 17, no. 11, article 1704, 2006. View at Publisher · View at Google Scholar · View at Scopus
  7. L. L. Lipscombe, S. A. Jamal, G. L. Booth, and G. A. Hawker, “The risk of hip fractures in older individuals with diabetes: a population-based study,” Diabetes Care, vol. 30, no. 4, pp. 835–841, 2007. View at Publisher · View at Google Scholar · View at Scopus
  8. D. E. Bonds, J. C. Larson, A. V. Schwartz et al., “Risk of fracture in women with type 2 diabetes: the women's health initiative observational study,” Journal of Clinical Endocrinology and Metabolism, vol. 91, no. 9, pp. 3404–3410, 2006. View at Publisher · View at Google Scholar · View at Scopus
  9. E. S. Strotmeyer, J. A. Cauley, A. V. Schwartz et al., “Nontraumatic fracture risk with diabetes mellitus and impaired fasting glucose in older white and black adults: the health, aging, and body composition study,” Archives of Internal Medicine, vol. 165, no. 14, pp. 1612–1617, 2005. View at Publisher · View at Google Scholar · View at Scopus
  10. E. S. Strotmeyer, J. A. Cauley, A. V. Schwartz et al., “Diabetes is associated independently of body composition with BMD and bone volume in older white and black men and women: the health, aging, and body composition study,” Journal of Bone and Mineral Research, vol. 19, no. 7, pp. 1084–1091, 2004. View at Publisher · View at Google Scholar · View at Scopus
  11. E. S. Strotmeyer, J. A. Cauley, A. V. Schwartz et al., “Reduced peripheral nerve function is related to lower hip BMD and calcaneal QUS in older white and black adults: the Health, Aging, and Body Composition Study,” Journal of Bone and Mineral Research, vol. 21, no. 11, pp. 1803–1810, 2006. View at Publisher · View at Google Scholar · View at Scopus
  12. G. N. Farhat, E. S. Strotmeyer, A. B. Newman et al., “Volumetric and areal bone mineral density measures are associated with cardiovascular disease in older men and women: the health, aging, and body composition study,” Calcified Tissue International, vol. 79, no. 2, pp. 102–111, 2006. View at Publisher · View at Google Scholar · View at Scopus
  13. L. F. Fried, M. G. Shlipak, C. Stehman-Breen et al., “Kidney function predicts the rate of bone loss in older individuals: the Cardiovascular Health Study,” Journals of Gerontology—Series A Biological Sciences and Medical Sciences, vol. 61, no. 7, pp. 743–748, 2006. View at Google Scholar · View at Scopus
  14. L. F. Fried, M. L. Biggs, M. G. Shlipak et al., “Association of kidney function with incident hip fracture in older adults,” Journal of the American Society of Nephrology, vol. 18, no. 1, pp. 282–286, 2007. View at Publisher · View at Google Scholar · View at Scopus
  15. K. E. Ensrud, L.-Y. Lui, B. C. Taylor et al., “Renal function and risk of hip and vertebral fractures in older women,” Archives of Internal Medicine, vol. 167, no. 2, pp. 133–139, 2007. View at Publisher · View at Google Scholar
  16. L. P. Fried, N. O. Borhani, P. Enright et al., “The cardiovascular health study: design and rationale,” Annals of Epidemiology, vol. 1, no. 3, pp. 263–276, 1991. View at Google Scholar
  17. A. B. Newman, A. M. Arnold, M. C. Sachs et al., “Long-term function in an older cohort—the cardiovascular health study all stars study,” Journal of the American Geriatrics Society, vol. 57, no. 3, pp. 432–440, 2009. View at Publisher · View at Google Scholar · View at Scopus
  18. M. Cushman, E. S. Cornell, P. R. Howard, E. G. Bovill, and R. P. Tracy, “Laboratory methods and quality assurance in the Cardiovascular Health Study,” Clinical Chemistry, vol. 41, no. 2, pp. 264–270, 1995. View at Google Scholar · View at Scopus
  19. A. B. Newman, D. S. Siscovick, T. A. Manolio et al., “Ankle-arm index as a marker of atherosclerosis in the cardiovascular health study,” Circulation, vol. 88, no. 3, pp. 837–845, 1993. View at Google Scholar · View at Scopus
  20. M. G. Shlipak, L. F. Fried, C. Crump et al., “Cardiovascular disease risk status in elderly persons with renal insufficiency,” Kidney International, vol. 62, no. 3, pp. 997–1004, 2002. View at Publisher · View at Google Scholar · View at Scopus
  21. A. S. Levey, K. U. Eckardt, Y. Tsukamoto et al., “Definition and classification of chronic kidney disease: a position statement from Kidney Disease: improving Global Outcomes (KDIGO),” Kidney International, vol. 67, no. 6, pp. 2089–2100, 2005. View at Publisher · View at Google Scholar · View at Scopus
  22. B. M. Psaty, M. Lee, P. J. Savage et al., “Assessing the use of medications in the elderly: mmethods and initial experience in the cardiovascular health study,” Journal of Clinical Epidemiology, vol. 45, no. 6, pp. 683–692, 1992. View at Publisher · View at Google Scholar
  23. H. L. Taylor, D. R. Jacobs, and B. Schucker, “A questionnaire for the assessment of leisure time physical activities,” Journal of Chronic Diseases, vol. 31, no. 12, pp. 741–755, 1978. View at Google Scholar · View at Scopus
  24. A. V. Schwartz, D. E. Sellmeyer, E. S. Strotmeyer et al., “Diabetes and bone loss at the hip in older black and white adults,” Journal of Bone and Mineral Research, vol. 20, no. 4, pp. 596–603, 2005. View at Publisher · View at Google Scholar · View at Scopus
  25. L. Forsén, H. E. Meyer, K. Midthjell, and T. H. Edna, “Diabetes mellitus and the incidence of hip fracture: results from the Nord-Trondelag health survey,” Diabetologia, vol. 42, no. 8, pp. 920–925, 1999. View at Publisher · View at Google Scholar · View at Scopus
  26. A. V. Schwartz, D. E. Sellmeyer, K. E. Ensrud et al., “Older women with diabetes have an increased risk of fracture: a prospective study,” Journal of Clinical Endocrinology and Metabolism, vol. 86, no. 1, pp. 32–38, 2001. View at Publisher · View at Google Scholar
  27. A. T. Hirsch, M. H. Criqui, D. Treat-Jacobson et al., “Peripheral arterial disease detection, awareness, and treatment in primary care,” JAMA, vol. 286, no. 11, pp. 1317–1324, 2001. View at Google Scholar · View at Scopus
  28. G. J. Hankey, P. E. Norman, and J. W. Eikelboom, “Medical treatment of peripheral arterial disease,” JAMA, vol. 295, no. 5, pp. 547–553, 2006. View at Publisher · View at Google Scholar · View at Scopus
  29. M. van der Klift, H. A. P. Pols, A. E. Hak, J. C. M. Witteman, A. Hofman, and C. E. D. H. De Laet, “Bone mineral density and the risk of peripheral arterial disease: the Rotterdam Study,” Calcified Tissue International, vol. 70, no. 6, pp. 443–449, 2002. View at Publisher · View at Google Scholar · View at Scopus
  30. S. Y. S. Wong, T. Kwok, J. Woo et al., “Bone mineral density and the risk of peripheral arterial disease in men and women: results from Mr. and Ms Os, Hong Kong,” Osteoporosis International, vol. 16, no. 12, pp. 1933–1938, 2005. View at Publisher · View at Google Scholar · View at Scopus
  31. L. Jørgensen, O. Joakimsen, G. K. R. Berntsen, I. Heuch, and B. K. Jacobsen, “Low bone mineral density is related to echogenic carotid artery plaques: a population-based study,” American Journal of Epidemiology, vol. 160, no. 6, pp. 549–556, 2004. View at Publisher · View at Google Scholar
  32. D. P. Kiel, L. I. Kauppila, L. A. Cupples, M. T. Hannan, C. J. O'Donnell, and P. W. F. Wilson, “Bone loss and the progression of abdominal aortic calcification over 25 year period: the Framingham Heart Study,” Calcified Tissue International, vol. 68, no. 5, pp. 271–276, 2001. View at Google Scholar · View at Scopus
  33. V. Baldini, M. Mastropasqua, C. M. Francucci, and E. D'Erasmo, “Cardiovascular disease and osteoporosis,” Journal of Endocrinological investigation, vol. 28, no. 10, pp. 69–72, 2005. View at Google Scholar · View at Scopus
  34. K. K. Nicodemus and A. R. Folsom, “Type 1 and type 2 diabetes and incident hip fractures in postmenopausal women,” Diabetes Care, vol. 24, no. 7, pp. 1192–1197, 2001. View at Google Scholar · View at Scopus
  35. R. Q. Ivers, R. G. Cumming, P. Mltchell, and A. J. Peduto, “Diabetes and risk of fracture: the blue mountains eye study,” Diabetes Care, vol. 24, no. 7, pp. 1198–1203, 2001. View at Google Scholar · View at Scopus
  36. L. J. Melton, C. L. Leibson, S. J. Achenbach, T. M. Therneau, and S. Khosla, “Fracture risk in type 2 diabetes: update of a population-based study,” Journal of Bone and Mineral Research, vol. 23, no. 8, pp. 1334–1342, 2008. View at Publisher · View at Google Scholar · View at Scopus
  37. E. S. Strotmeyer, J. A. Cauley, T. J. Orchard, A. R. Steenkiste, and J. S. Dorman, “Middle-aged premenopausal women with type 1 diabetes have lower bone mineral density and calcaneal quantitative ultrasound than nondiabetic women,” Diabetes Care, vol. 29, no. 2, pp. 306–311, 2006. View at Google Scholar · View at Scopus
  38. K. J. Ottenbacher, G. V. Ostir, M. Kristen Peek, J. S. Goodwin, and K. S. Markides, “Diabetes mellitus as a risk factor for hip fracture in Mexican American older adults,” Journals of Gerontology—Series A Biological Sciences and Medical Sciences, vol. 57, no. 10, pp. M648–M653, 2002. View at Google Scholar · View at Scopus
  39. C. Wallace, G. E. Reiber, J. LeMaster et al., “Incidence of falls, risk factors for falls, and fall-related fractures in individuals with diabetes and a prior foot ulcer,” Diabetes Care, vol. 25, no. 11, pp. 1983–1986, 2002. View at Publisher · View at Google Scholar · View at Scopus
  40. S. R. Cummings, M. C. Nevitt, W. S. Browner et al., “Risk factors for hip fracture in white women. Study of Osteoporotic Fractures Research Group,” The New England Journal of Medicine, vol. 332, pp. 767–773, 1995. View at Google Scholar
  41. P. M. Cawthon, R. L. Fullman, L. Marshall et al., “Physical performance and risk of hip fractures in older men,” Journal of Bone and Mineral Research, vol. 23, no. 7, pp. 1037–1044, 2008. View at Publisher · View at Google Scholar · View at Scopus
  42. J. K. Richardson and J. A. Ashton-Miller, “Peripheral neuropathy: an often-overlooked cause of falls in the elderly,” Postgraduate Medicine, vol. 99, no. 6, pp. 161–172, 1996. View at Google Scholar · View at Scopus
  43. M. F. Holick, “Diabetes and the vitamin D connection,” Current Diabetes Reports, vol. 8, no. 5, pp. 393–398, 2008. View at Publisher · View at Google Scholar · View at Scopus
  44. S. E. Kahn, S. M. Haffner, M. A. Heise et al., “Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy,” The New England Journal of Medicine, vol. 355, no. 23, pp. 2427–2443, 2006. View at Publisher · View at Google Scholar
  45. E. S. Strotmeyer, A. V. Schwartz, and A. B. Newman, “Thiazolidinediones and the risk of nontraumatic fractures in patients with diabetes: in reply,” Archives of Internal Medicine, vol. 166, no. 9, article 1043, 2006. View at Google Scholar · View at Scopus
  46. U. Sennerby, H. Melhus, R. Gedeborg et al., “Cardiovascular diseases and risk of hip fracture,” JAMA, vol. 302, no. 15, pp. 1666–1673, 2009. View at Publisher · View at Google Scholar · View at Scopus