Sterol Lipid Metabolism in Down Syndrome Revisited: Down Syndrome Is Associated with a Selective Reduction in Serum Brassicasterol Levels

Table 2

Serum analytes in the total control and total DS cohorts. Analytes shown in bold are significantly different between control and DS groups by unpaired Student’s 𝑡-test. Welch’s correction was applied when variances were significantly different between groups.

	Con	DS	𝑃
TC (mmol/L)	4.858 (±0.743)	4.925 (±1.123)	0.834
HDL-C (mmol/L)	1.591(±0.514)	1.412 (±0.271)	0.116
ApoA-I (mg/mL)	1.4266 (±0.245)	1.324 (±0.179)	0.051
ApoB (mg/mL)	0.8028 (±0.176)	0.9015 (±0.255)	0.178
CRP (mmol/L)	1.361 ( ± 1.767)	2.847 ( ± 2.101)	0.035
Campesterol (mg/dL)	0.4953 (±0.279)	0.3424 (±0.194)	0.056
Sitosterol (mg/dL)	0.4040 ( ± 0.196)	0.2716 ( ± 0.153)	0.025
24S-OH cholesterol	64.06 (±2.540)	69.90 (±5.199)	0.296
Lathosterol (mg/dL)	0.1930 (±0.097)	0.225 (±0.130)	0.401
Campestanol (mg/dL)	3.552 (±1.385)	3.368 (±1.811)	0.729
Stigmasterol (𝜇g/dL)	9.721 (±0.602)	11.93 (±1.115)	0.092
Sitostanol (mg/dL)	4.586 (±0.255)	4.347 (±0.436)	0.639
Lanosterol (𝜇g/dL)	17.50 (±9.01)	21.11 (±11.17)	0.284
Dihydrolanosterol (𝜇g/dL)	13.33 (±2.304)	14.65 (±4.385)	0.260
Desmosterol (mg/dL)	0.1401 (±0.052)	0.1295 (±0.067)	0.595
7𝛼-OH-cholesterol (ng/mL)	72.33 (±101.0)	98.95 (±84.29)	0.382
Cholesterol (mg/dL)	185.4 (±27.51)	209.3 (±47.96)	0.071
27-OH cholesterol (ng/mL)	185.0 ( ± 54.84)	135.0 ( ± 44.69)	0.004
Cholestanol (mg/dL)	0.2825 ( ± 0.060)	0.3501 ( ± 0.088)	0.010
Brassicasterol (𝜇g/dL)	32.07 ( ± 3.802)	11.16 ( ± 1.518)	<0.0001