The Use of Mouse Models for Understanding the Biology of Down Syndrome and Aging

Figure 1

A graphical representation of HSA21 and the syntenic mouse chromosome regions from Mmu10, Mmu16, and Mmu17. The trisomic (or monosomic) chromosome regions present in 10 of the segmental mouse trisomies are also shown, with color-coding indicating the chromosome source of the region (see the key in the figure). The location of 11 HSA21 genes is shown, as well as their location on the syntenic chromosome regions, with text color indicating which syntenic chromosome. The dark ovals indicate the HSA21 centromere.