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Current Gerontology and Geriatrics Research
Volume 2017 (2017), Article ID 4276047, 5 pages
Research Article

Diseases Linked to Polypharmacy in Elderly Patients

2nd Department of Internal Medicine, General and Oncological Hospital of Kifissia “Agioi Anargyroi”, Noufaron and Timiou Stavrou 14, Athens, Greece

Correspondence should be addressed to Ioannis Vrettos

Received 27 October 2017; Accepted 7 December 2017; Published 25 December 2017

Academic Editor: Tomasz Kostka

Copyright © 2017 Ioannis Vrettos et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Introduction. Polypharmacy in several cases is deemed necessary and elderly patients are prone to this phenomenon. The objective of this study was to identify the prevalence and the predictors of polypharmacy among consecutively unplanned admissions of patients aged ≥65 years. Patients and Methods. In 310 patients (51% women), mean age 80.24 years (95% CI 79.35–81.10), demographic characteristics, medical history, medications, and cause of admission were recorded. Parametric tests and multiple logistic regression analysis were applied to identify the factors that have significant association with polypharmacy. Results. 53.5% of patients belonged to polypharmacy group. In multivariate analysis the independent predictors of polypharmacy were arterial hypertension (, OR = 2.708, and 95% CI 1.400–5.238), coronary artery disease (, OR = 8.274, and 95% CI 3.161–21.656), heart failure (, OR = 4.042, and 95% CI 1.145–14.270), atrial fibrillation (, OR = 2.477, and 95% CI 1.086–5.648), diabetes mellitus (, OR = 2.390, and 95% CI 1.232–4.636), dementia (, OR = 4.637, and 95% CI 1.876–11.464), and COPD (, OR = 3.626, and 95% CI 1.208–10.891). Conclusions. Polypharmacy mainly was linked to cardiovascular diseases. If deprescribing is not feasible, physicians must oversee those patients in order to recognise early, possible drug reactions.