Table of Contents
Chemotherapy Research and Practice
Volume 2014, Article ID 570241, 9 pages
http://dx.doi.org/10.1155/2014/570241
Research Article

Ferric Carboxymaltose-Mediated Attenuation of Doxorubicin-Induced Cardiotoxicity in an Iron Deficiency Rat Model

1Hospital Alemán, Laboratory of Experimental Medicine, School of Medicine, Avenue Pueyrredon 1640, 1118 Buenos Aires, Argentina
2Instituto de Química y Fisicoquímica Biológica (UBA-CONICET), Facultad de Farmacia y Bioquímica, University of Buenos Aires, Buenos Aires, Argentina
3Vifor (International) AG, Rechenstrasse 37, 9014 St. Gallen, Switzerland
4Vifor Pharma, 1203-4464 Markham Street, Victoria, BC, Canada V8Z 7X8

Received 25 December 2013; Accepted 25 March 2014; Published 30 April 2014

Academic Editor: H. J. Schmoll

Copyright © 2014 Jorge Eduardo Toblli et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

DOX-associated nephrotoxicity and its modulation with FCM were characterised in SHR-SP rats with IDA that was induced by low iron diet. The assessments involved the following evaluations at study end: renal function (creatinine clearance, 24 h proteinuria, urine NGAL), oxidative stress (GSH:GSSG ratio, MDA, catalase, Cu,Zn-SOD, GPx activity), histological and immunohistochemical parameters (Masson's Trichrome and Sirius Red staining, immunodetection of TNF-alpha, IL-6, iNOS, nitrotyrosine and ferritin L-chain).

  1. Supplementary Material