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Computational Intelligence and Neuroscience
Volume 2010, Article ID 164278, 5 pages
Research Article

Simultaneous EEG-fMRI in Patients with Unverricht-Lundborg Disease: Event-Related Desynchronization/Synchronization and Hemodynamic Response Analysis

1Department of Neurophysiopathology, “Carlo Besta” IRCCS Neurological Institute, 20133 Milan, Italy
2Department of Neuroradiology, “Carlo Besta” IRCCS Neurological Institute, 20133 Milan, Italy
3Scientific Department, “Carlo Besta” IRCCS Neurological Institute, 20133 Milan, Italy

Received 12 June 2009; Revised 3 September 2009; Accepted 14 October 2009

Academic Editor: Fabio Babiloni

Copyright © 2010 Elisa Visani et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We performed simultaneous acquisition of EEG-fMRI in seven patients with Unverricht-Lundborg disease (ULD) and in six healthy controls using self-paced finger extension as a motor task. The event-related desynchronization/synchronization (ERD/ERS) analysis showed a greater and more diffuse alpha desynchronization in central regions and a strongly reduced post-movement beta-ERS in patients compared with controls, suggesting a significant dysfunction of the mechanisms regulating active movement and movement end. The event-related hemodynamic response obtained from fMRI showed delayed BOLD peak latency in the contralateral primary motor area suggesting a less efficient activity of the neuronal populations driving fine movements, which are specifically impaired in ULD.