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Computational Intelligence and Neuroscience
Volume 2010 (2010), Article ID 254032, 8 pages
Research Article

DTI Parameter Optimisation for Acquisition at 1.5T: SNR Analysis and Clinical Application

1Polo Tecnologico, Fondazione Don Gnocchi ONLUS, IRCCS S. Maria Nascente, 20148 Milano, Italy
2Department of Bioengineering, Politecnico di Milano, 20133 Milan, Italy
3U.O. Sclerosi Multipla, Fondazione Don Gnocchi ONLUS, IRCCS S. Maria Nascente, 20148 Milano, Italy

Received 13 July 2009; Accepted 7 October 2009

Academic Editor: Fabio Babiloni

Copyright © 2010 M. Laganà et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Magnetic Resonance (MR) diffusion tensor imaging (DTI) is able to quantify in vivo tissue microstructure properties and to detect disease related pathology of the central nervous system. Nevertheless, DTI is limited by low spatial resolution associated with its low signal-to-noise-ratio (SNR). Aim. The aim is to select a DTI sequence for brain clinical studies, optimizing SNR and resolution. Methods and Results. We applied 6 methods for SNR computation in 26 DTI sequences with different parameters using 4 healthy volunteers (HV). We choosed two DTI sequences for their high SNR, they differed by voxel size and b-value. Subsequently, the two selected sequences were acquired from 30 multiple sclerosis (MS) patients with different disability and lesion load and 18 age matched HV. We observed high concordance between mean diffusivity (MD) and fractional anysotropy (FA), nonetheless the DTI sequence with smaller voxel size displayed a better correlation with disease progression, despite a slightly lower SNR. The reliability of corpus callosum (CC) fiber tracking with the chosen DTI sequences was also tested. Conclusion. The sensitivity of DTI-derived indices to MS-related tissue abnormalities indicates that the optimized sequence may be a powerful tool in studies aimed at monitoring the disease course and severity.