Biochemical Frequency Control by Synchronisation of Coupled Repressilators: An In Silico Study of Modules for Circadian Clock Systems

Figure 7

General scheme of a pure chemical frequency control system based on the concept of phase-locked loops (PLLs). The upper part shows the coupling structure of the three essential modules: core oscillator, signal comparator, and low-pass filter. Each module can be represented by numerous reaction networks. For instance, complex formation suffices for acting as signal comparator while a signalling cascade exemplifies a low-pass filter. Different types of core oscillators complete the control circuit.