Modeling Spike-Train Processing in the Cerebellum Granular Layer and Changes in Plasticity Reveal Single Neuron Effects in Neural Ensembles
Figure 1
Granular layer network topology. (a) Network topology map. Granule cells (GrCs) receive 1–4 excitatory inputs from mossy fibers. GrC receive 0 (no inhibition)–4 inhibitory inputs from GoC via the GABAergic synapses, one per granule neuron dendrite. The ratio is about 4000 : 1 [1]. Granular layer processing is fast and usually output spikes are seen in millisecond time intervals. (b) Detailed granule neuron model adapted from [19]. (c) Extracellular mechanism to study extracellular current flow in compartmental models. This mechanism was used to model LFP (see Section 2.6).
