Analyzing the Effects of Gap Junction Blockade on Neural Synchrony via a Motoneuron Network Computational Model
Example of simulation showing the effects of gap junction uncoupling. The biological simulated time was 8 seconds on a network of 100 motoneurons. (a) Voltage traces from a selection of 20 of the neurons; upper panel shows expanded traces from 3 regions indicated, demonstrating perfect synchrony during the initial segment, the reduction of synchrony as the neurons are uncoupling during the second segment, and unsynchronized firing in the final segment. (b) Average gap junction conductance (in nS). (c) Integrated total voltage trace of the entire network. (d) The measure of synchrony of the network with data points every 200 ms.