Spectral Gini Index for Quantifying the Depth of Consciousness

Table 3

Population pharmacokinetic parameter estimates, interindividual variability, and median parameter values (2.5–97.5%) of the nonparametric bootstrap replicates of the final pharmacokinetic model of propofol.

Parameters	Unit		Estimates (RSE, %)	CV (%)	Median (2.5–97.5%)
	L		10.3 (6.4)	10.7	10.3 (9.3–11.7)
			6.63 (15.7)		6.4 (4.3–10.8)
	L		75.3 (9.4)	—	75.3 (62.6–88.4)
	L		846 (41.0)	—	861 (505.9–1600)
	L/min		0.217 (49.3)	11.2	0.214 (0.00002–0.36)
			1.02 (43.3)		0.99 (0.0005–1.79)
	L/min		0.928 (6.1)	—	0.928 (0.829–1.05)
	L/min		0.679 (13.2)	19.3	0.703 (0.569–0.895)
	—		0.083 (9.8)	—	0.081 (0.066–0.095)

A log-normal distribution of interindividual random variability was assumed. Residual random variability was modeled using constant CV error model. Nonparametric bootstrap analysis was repeated 1000 times. RSE: relative standard error = SE/mean × 100 (%). LBM: lean body mass calculated using the Janmahasatian formula [29], WT: body weight, : central volume of distribution (), : rapid peripheral , : slow peripheral , Cl: metabolic clearance, : intercompartmental clearance between central and rapid peripheral compartments, and : intercompartmental clearance between central and slow peripheral compartments.